PMID

Data

Article Title

Organization

Synthesis of quaternarya-amino acid-based arginase inhibitors via the Ugi reaction.

Institutes For Pharmaceutical Discovery

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.

Institutes For Pharmaceutical Discovery

Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.

Institutes For Pharmaceutical Discovery

Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8.

Drexel University

Binding ofa,a-disubstituted amino acids to arginase suggests new avenues for inhibitor design.

Drexel University

2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.

University of Pennsylvania

Amino-cyclohexane Carboxylic Acid Inhibitors of Arginase.

Arrival Discovery

Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.

Merck

Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.

Quantitative Biosciences

Boronic acid-based arginase inhibitors in cancer immunotherapy.

Oncoarendi Therapeutics

Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors.

Univ. Bourgogne Franche-Comt�

Novel Arginase Inhibitors for Treating Cancer and Respiratory Inflammatory Diseases.

Smith, Gambrell & Russell

Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.

Merck

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.

Universit£

Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors.

Oncoarendi Therapeutics

Discovery of

New England Discovery Partners

Rational design of novel irreversible inhibitors for human arginase.

Brown University

Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV.

Takeda Pharmaceutical