The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.9M data for 1.2M Compounds and 9.3K Targets. Of those, 1,352K data for 627K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Advanced Search

15 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups.EBI
Duke University
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.EBI
Merck Research Laboratories
Structure-based discovery of LpxC inhibitors.EBI
Cubist Pharmaceuticals
Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.EBI
Kyorin Pharmaceutical
LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents.EBI
Kyorin Pharmaceutical
Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors.EBI
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.EBI
Duke University
Exploring the UDP pocket of LpxC through amino acid analogs.EBI
Astrazeneca
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.EBI
Pfizer
Design and synthesis of potent Gram-negative specific LpxC inhibitors.EBI
Merck Research Laboratories
Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.EBI
Jilin University
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.EBI
Duke University Medical Center