53 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease.
Tehran University of Medical Sciences
Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.
Bar-Ilan University
Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection.
Punjabi University
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.
Universit£
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Universitat De Barcelona
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
Bar-Ilan University
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.
Instituto De Qu£Mica M£Dica
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.
Universitat De Barcelona
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
Universidad Autonoma De Madrid
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.
Institute of Plant Biochemistry
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Universit£
Brunneins A-C, beta-carboline alkaloids from Cortinarius brunneus.
Institute of Plant Biochemistry
Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum.
Hoshi University
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Universitat De Barcelona
Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.
University of Hamburg
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Universit£
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.
Institute of Research
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.
Universitat De Barcelona
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Universitat De Barcelona
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
Universitat De Barcelona
Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.
University of Iowa
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Sri International
Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.
Georgetown University Medical Center
Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.
Georgetown University Medical Center
Synthesis of ()-10,10-dimethylhuperzine A a huperzine analogue possessing a slower enzyme off-rate
TBA
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Instituto De Qu£Mica M£Dica
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.
Universit£
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.
Universidad De Granada
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.
Instituto De Qu£Mica M£Dica
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.
Instituto De Quimica Medica
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Instituto De Quimica Medica (Csic)
Synthesis, insecticidal and anti-acetylcholinesterase activity of a new class of heterocyclic methanesulfonates
TBA
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.
Università
Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase.
Hoshi University
Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase.
Hoshi University
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease.
Lanzhou University
Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.
Hospital Universitario De La Princesa
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.
Istituto Di Strutturistica Chimica G. Giacomello
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Csir-Central Drug Research Institute
Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.
University of North Texas
Benzopyrroloxazines containing a bridgehead nitrogen atom as promising scaffolds for the achievement of biologically active agents.
University of Calabria
Success stories of natural product-based hybrid molecules for multi-factorial diseases.
Punjabi University
Rational design of carbamate-based dual binding site and central AChE inhibitors by a "biooxidisable" prodrug approach: Synthesis, in vitro evaluation and docking studies.
Cnrs
Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.
China Pharmaceutical University
Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
Merck Frosst Centre For Therapeutic Research
Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors.
Fujisawa Pharmaceutical
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
St. Jude Research Hospital