PMID

Data

Article Title

Organization

Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.

Moltech

The GABA(A) receptor as a target for photochromic molecules.

University of Massachusetts

Design, synthesis, and subtype selectivity of 3,6-disubstitutedß-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.

University of Wisconsin-Milwaukee

Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based ?-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect.

University of Copenhagen

Structural Determinants for the Mode of Action of Imidazopyridine DS2 at ?-Containing ?-Aminobutyric Acid Type A Receptors.

University of Copenhagen

An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.

Merck Sharp & Dohme Research Laboratories

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

Merck Sharp and Dohme Research Laboratories

Neuroactive Type-A ?-Aminobutyric Acid Receptor Allosteric Modulator Steroids from the Hypobranchial Gland of Marine Mollusk,

University of Utah

Tricyclic pyridones as functionally selective human GABAA alpha 2/3 receptor-ion channel ligands.

The Neuroscience Research Centre

Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis.

University of Wisconsin-Milwaukee

Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist.

University of Wisconsin-Milwaukee

Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors.

The Royal Danish School of Pharmacy

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at ?-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters.

University of Copenhagen

Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors.

Amgen

Neuroactive Steroids. 2. 3?-Hydroxy-3?-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5?-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (?-Aminobutyric Acid)

Sage Therapeutics

Structural Requirements for Eszopiclone and Zolpidem Binding to the gamma-Aminobutyric Acid Type-A (GABAA) Receptor Are Different.

University of Wisconsin At Madison

A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.

University of Wisconsin-Milwaukee