PMID

Data

Article Title

Organization

Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology.

Merck Research Laboratories

Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.

Glaxosmithkline

Structural basis of pharmacological chaperoning for human ß-galactosidase.

The University of Tokyo

A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.

University of Ferrara

Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation.

Tohoku University

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.

Anadys Pharmaceuticals

Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.

Sapienza University of Rome

Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid.

Monash University

Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.

Universita Degli Studi Di Firenze

The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.

Gsk

Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.

Merck Research Laboratories