PMID

Data

Article Title

Organization

Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.

Merck

Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators.

Pfizer

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.

Pfizer

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.

Chinese Academy of Sciences

Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease.

Cellzome

A quantitative analysis of kinase inhibitor selectivity.

Ambit Biosciences

Comprehensive analysis of kinase inhibitor selectivity.

Ambit Biosciences

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

Ambit Biosciences

Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.

Pfizer

Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.

University of Colorado Anschutz Medical Campus

Discovery and optimization of heteroaryl piperazines as potent and selective PI3K? inhibitors.

Merck

Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPK?2?1?1 activators.

Nanjing University of Chinese Medicine

Discovery of 4

TBA

Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.

Takeda Pharmaceutical

Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).

Pfizer

Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations.

Glaxosmithkline

Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng.

Chinese Academy of Sciences

Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase.

Metabasis Therapeutics

 

CDK2 in CSAR_FULL_RELEASE_3JULY2012

Csar

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Johnson & Johnson Pharmaceutical