PMID

Data

Article Title

Organization

 

Synthesis and serotonergic activity of benzofuran and dihydrogenzofuran analogues of 5-carboxamidotryptamine.

TBA

Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.

H. Lundbeck

Bivalent Ligands for the Serotonin 5-HT3 Receptor.

TBA

Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.

European Research Centre For Drug Discovery and Development (Natsyndrugs)

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.

Pfizer

Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.

University of Florida

 

New aza(nor)adamantanes are agonists at the newly identified serotonin 5-HT4 receptor and antagonists at the 5-HT3 receptor

TBA

Optimization of 5-pyridazin-3-one phenoxypropylamines as potent, selective histamine H3 receptor antagonists with potent cognition enhancing activity.

Cephalon

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

Universidad Complutense De Madrid

Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors.

Hungarian Academy of Sciences

Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.

TBA

 

(S)-4-amino-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptor

TBA

Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

European Research Centre For Drug Discovery and Development (Natsyndrugs)

Novel sigma receptor ligands: synthesis and biological profile.

University of Catania

Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT

Jagiellonian University Medical College

New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.

Universidad De Navarra

Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.

Indiana State University

Synthesis, biological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors.

University of Karachi

Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis.

The M. S. University of Baroda