PMID

Data

Article Title

Organization

8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors.

National Institute of Diabetes, Digestive and Kidney Diseases

5'-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor.

Leiden University

2-aralkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.

University of South Florida

Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.

Kyowa Hakko Kogyo

Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.

Niddk

2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.

Universit£

Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.

Universit£

125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.

University of Virginia School of Medicine

N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.

TBA

(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.

Virginia Commonwealth University

 

Discovery of FK453, a novel non-xanthine adenosine A₁ receptor antagonist

TBA

Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.

Columbia University College of Physicians and Surgeons

Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.

Columbia University College of Physicians and Surgeons

Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.

Palack£

Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.

Hokuriku University

Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.

Merrell Dow Research Institute

Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.

TBA

Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.

National Institutes of Health

2-(N'-alkylidenehydrazino)adenosines: potent and selective coronary vasodilators.

University of South Florida

7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.

Kyowa Hakko Kogyo

Effects of alkyl substitutions of xanthine skeleton on bronchodilation.

Hokuriku University