Binding Database

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.

Entremed

Potent Uncompetitive Inhibitors of Nicotinamide

Harvard University

Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides.

Shionogi

Potent Inhibition of Nicotinamide

Leiden University

Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.

Shionogi

Novel Pyrimidine-5-carboxamide Compounds as NNMT Inhibitors for Treating Diabetes.

Smith, Gambrell & Russell

High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide

Biokin

Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1.

Purdue University

Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for Nicotinamide

TBA

Bisubstrate Inhibitors of Nicotinamide

Leiden University

Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ.

The Scripps Research Institute

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.

Sanofi-Aventis Deutschland

Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).

Icahn School of Medicine At Mount Sinai