PMID

Data

Article Title

Organization

Sulfonamides as Selective Na

Amgen

Sulfonamides as Selective Na

Amgen

Sulfonamides as Selective Na

Amgen

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.

Xenon Pharmaceuticals

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.

Amgen

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.

Merck Research Laboratories

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.

Amgen

Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.

University College London

Ion channels as therapeutic targets: a drug discovery perspective.

Pfizer

2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers.

Universit£

3-(4-phenoxyphenyl)pyrazoles: a novel class of sodium channel blockers.

Purdue Pharma

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Amgen

Discovery of Selective Inhibitors of Na

Siteone Therapeutics

Discovery of Acyl-sulfonamide Na

Genentech

Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na

Merck

Design, synthesis, and evaluation of analogues of 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionamide as orally available general anesthetics.

University of Virginia

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I

Gilead Sciences

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.

Amgen

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Na

Genentech

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na

Bristol-Myers Squibb Research and Development

The discovery and optimization of benzimidazoles as selective Na

Pfizer

Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na

Siteone Therapeutics

Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators.

University of Ljubljana

Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges.

University of Ljubljana

Discovery of aminocyclohexene analogues as selective and orally bioavailable hNav1.7 inhibitors for analgesia.

Wuxi Apptec (Shanghai)

Highly potent and selective Na

Pfizer

Discovery of Tarantula Venom-Derived Na

Amgen

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na

Icagen

Inhibitors of HIV-1 proteinase containing 2-heterosubstituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, enzyme inhibition, and antiviral activity.

Sandoz Forschungsinstitut Ges.M.B.H.