24 articles for thisTarget
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Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
University of California Davis
Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors.
Sumitomo Dainippon Pharma
Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action.
Dainippon Sumitomo Pharma
Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases.
Toray Industries
Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension.
Toray Industries
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.
Glaxosmithkline
A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors.
Dainippon Sumitomo Pharma
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
Merck Research Laboratories
Orally bioavailable potent soluble epoxide hydrolase inhibitors.
University of California Davis
Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method.
Boehringer Ingelheim Pharmaceuticals
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.
Merck Research Laboratories
Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.
Boehringer Ingelheim Pharmaceuticals
Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase.
Boehringer Ingelheim Pharmaceuticals
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors.
Merck Research Laboratories
Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase.
Boehringer Ingelheim Pharmaceuticals
Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.
Merck Research Laboratories
2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors:
Universitat De Barcelona
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.
Goethe-University Frankfurt
Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.
University of California Davis
Adamantyl thioureas as soluble epoxide hydrolase inhibitors.
University of California Davis