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Synthesis of new derivatives of 21-imidazolyl-16-dehydropregnenolone as inhibitors of 5a-reductase 2 and with cytotoxic activity in cancer cells.

Universidad Nacional Aut£Noma De M£Xico

Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5a-reductase inhibitors.

University Institute of Pharmaceutical Sciences

Synthesis and activity of novel 16-dehydropregnenolone acetate derivatives as inhibitors of type 1 5a-reductase and on cancer cell line SK-LU-1.

Universidad Nacional Aut£Noma De M£Xico

Effect of dehydroepiandrosterone derivatives on the activity of 5a-reductase isoenzymes and on cancer cell line PC-3.

National University of Mexico

Benzophenone- and indolecarboxylic acids: potent type-2 specific inhibitors of human steroid 5 alpha-reductase.

Smithkline Beecham Pharmaceuticals

Steroidal A ring aryl carboxylic acids: a new class of steroid 5 alpha-reductase inhibitors.

Smith Kline & French Laboratories

 

A non-steroidal diene acid inhibitor of human type 2 stereoid 5-reductase

TBA

 

Preparative chiral HPLC separation of all possible stereoisomers of LY191704 and LY266111 and their in vitro inhibition of human types 1 and 2 steroid 5-reductases

TBA

Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5a-reductase inhibitors: a legitimate approach.

Panjab University

Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.

University of Maryland

Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors.

Saarland University

Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.

University of The Saarland

Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1.

Universit£

Pharmacological options in the treatment of benign prostatic hyperplasia.

Pfizer

19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2.

Universit£

Synthesis and in vitro evaluation of 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17 beta-carboxamides as 5 alpha-reductase inhibitors and antiandrogens.

Chul Research Center

Synthesis and in vitro activity of 17 beta-(N-alkyl/arylformamido)- and 17 beta-[(N-alkyl/aryl)alkyl/arylamido]-4-methyl-4-aza-3-oxo-5 alpha-androstan-3-ones as inhibitors of human 5 alpha-reductases and antagonists of the androgen receptor.

Chul Research Center

4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.

Merck Research Laboratories

Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.

Glaxo Inc. Research Institute

4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.

Merck Research Laboratories

6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase.

Glaxo Inc. Research Institute

Nonsteroidal inhibitors of human type I steroid 5-alpha-reductase.

Eli Lilly

Biphenyls as surrogates of the steroidal backbone. Part 2: discovery of a novel family of non-steroidal 5-alpha-reductase inhibitors.

Aventis

Synthesis of benzo[c]quinolizin-3-ones: selective non-steroidal inhibitors of steroid 5 alpha-reductase 1.

Universit£

Discovery of a novel hybrid from finasteride and epristeride as 5a-reductase inhibitor.

College of Chemical and Environmental Engineering

 

The preparation and evaluation of (+/-)-trans-1-Diazo-8-methoxy-4a-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-2-one as an inhibitor of human type-1 steroid 5α-reductase

TBA

 

A comparison of steroidal and non-steroidal inhibitors of human steroid 5α-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme

TBA

 

Inhibition of steroid 5α-reductase by “inverted”, competitive inhibitors

TBA

 

Inhibition of steroid 5α-reductase by 3-nitrosteroids: synthesis, mechanism of inhibition, and in vivo activity.

TBA

Evaluation of 4'-substituted bicyclic pyridones as non-steroidal inhibitors of steroid 5alpha-reductase.

University of Canterbury

Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids.

Saarland University

Recent advances on synthesis and biological activities of C-17 aza-heterocycle derived steroids.

Changzhi University

Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5alpha-reductases 1 and 2.

Polo Scientifico Università

Synthesis, biological activity, and three-dimensional quantitative structure-activity relationship model for a series of benzo[c]quinolizin-3-ones, nonsteroidal inhibitors of human steroid 5alpha-reductase 1.

University of Florence

Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).

University of The Saarland

Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase.

University of Canterbury

Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1.

Università

N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I and II inhibitory activity.

UniversitäT Des Saarlandes

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

Bristol-Myers Squibb

Synthesis and 5 alpha-reductase inhibitory activity of 8-substituted benzo[f]quinolinones derived from palladium mediated coupling reactions.

Eli Lilly

Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group.

Sankyo

6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase.

Glaxo Inc. Research Institute

Inhibition of steroid 5 alpha-reductase by unsaturated 3-carboxysteroids.

Smith Kline & French Laboratories

Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5?-androst-17?-amide derivatives as dual 5?-reductase inhibitors and androgen receptor antagonists.

China Pharmaceutical University