263 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.
University of Lille
The design of 8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors.
Glaxosmithkline
Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.
Shandong University
Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.
Universit£
Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.
University of Minnesota
Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors.
Beijing University of Technology
Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.
Glaxosmithkline
Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
Bristol-Myers Squibb Research and Development
A review on recent developments of indole-containing antiviral agents.
Central China Normal University
Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase.
Shandong University
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.
Boehringer Ingelheim (Canada)
4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.
National Institutes of Health
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.
South China Normal University
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.
University of Lille
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
Boehringer Ingelheim (Canada)
A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.
Universit£
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.
Sapienza University of Rome
Application of CoMFA and CoMSIA 3D-QSAR and docking studies in optimization of mercaptobenzenesulfonamides as HIV-1 integrase inhibitors.
University of Southern California
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.
University of Tennessee Health Science Center
Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.
Bristol-Myers Squibb
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.
National Cancer Institute/Nih
Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives.
Cnrs Umr 8532
Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication.
University of California
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.
Sapienza University of Rome
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
National Cancer Institute-Bethesda
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.
National Cancer Institute-Bethesda
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.
National Cancer Institute-Bethesda
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
National Cancer Institute-Bethesda
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.
National Cancer Institute-Bethesda
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.
University of Houston
Binding modes of two novel dinucleotide inhibitors of HIV-1 integrase.
The University of Iowa
Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides.
Institute of Science and Technology
Ring substituent effects on biological activity of vinyl sulfones as inhibitors of HIV-1.
University of California
Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome.
University of Southern California
Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.
Graduate School of The Chinese Academy of Sciences
From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.
Università
Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors.
Utrecht University
Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring.
Gilead Sciences
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.
Gilead Sciences
4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.
University of Minnesota
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Merck Research Laboratories
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.
Sapienza University of Rome
Dynamic pharmacophore model optimization: identification of novel HIV-1 integrase inhibitors.
University of Houston
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.
Central Pharmaceutical Research Institute
Beta-diketo acids with purine nucleobase scaffolds: novel, selective inhibitors of the strand transfer step of HIV integrase.
University of Georgia
HIV integrase inhibitors with nucleobase scaffolds: discovery of a highly potent anti-HIV agent.
University of Georgia
Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase.
University of Southern California
Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors.
Jagiellonian University
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors
Shandong University
Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis.
Université
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Merck Research Laboratories
Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors.
University of California
Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
University of Newcastle
Recent insight into the biological activities and SAR of quinolone derivatives as multifunctional scaffold.
Maharishi Markandeshwar (Deemed To Be University)
Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs.
University of Belgrade
Meroterpenoids produced by fungi: Occurrence, structural diversity, biological activities, and their molecular targets.
Guangzhou University of Chinese Medicine
Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.
Tibotec
Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors.
University of Houston
Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis.
Chinese Academy of Sciences
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase.
"Sapienza" Universit£
Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.
National Cancer Institute-Frederick
HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.
Italy. Vinc
Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.
Università
Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase.
Institute of Materia Medica
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.
Cnrs Umr 8076
6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays.
Sapienza University of Rome
Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.
Nci-Frederick
Catechol-substituted L-chicoric acid analogues as HIV integrase inhibitors.
Institute of Science & Technology
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.
National Cancer Institute-Bethesda
Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.
Purdue University
Four novel bis-(naphtho-gamma-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase.
Merck Research Laboratories
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
Merck Research Laboratories
Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Bristol Myers Squibb
Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives.
Université
DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n).
Russian Academy of Sciences
Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase.
The University of Iowa
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase.
"Sapienza" Universit£
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
Merck Research Laboratories
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Bristol-Myers Squibb Research & Development
Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGF/p75 disruptors and inhibitors of microbial pathogens.
University of The Witwatersrand
3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.
University of Minnesota
Advances in rationally designed dual inhibitors of HIV-1 reverse transcriptase and integrase.
Wuhan Institute of Technology
3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.
University of Minnesota
Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.
Université
Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity.
Merck Research Laboratories
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
Bristol-Myers Squibb Research and Development
Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review.
Wuhan University of Technology
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.
University of Minnesota
Lamellarin alpha 20-sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture.
Institute of Chemical Technology
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.
Shandong University
Chicoric acid analogues as HIV-1 integrase inhibitors.
National Cancer Institute-Bethesda
Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases.
University of Iowa
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.
University of Cagliari
Biological evaluation of molecules of the azaBINOL class as antiviral agents: Inhibition of HIV-1 RNase H activity by 7-isopropoxy-8-(naphth-1-yl)quinoline.
Oregon State University
Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.
National Cancer Institute-Bethesda
Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.
Paris-Sud University
An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
The Ohio State University
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
National Cancer Institute-Bethesda
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
Freie UniversitäT Berlin
Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors.
University of Delhi
Synthesis of dihydropyrimidine ?,?-diketobutanoic acid derivatives targeting HIV integrase.
Univ. Orl£Ans Et Cnrs
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.
"Sapienza" Universit£
Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.
Universit£
Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.
Universit£
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.
"Sapienza" Universit£
Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.
National Cancer Institute-Frederick
Inhibiting the HIV integration process: past, present, and the future.
"Sapienza" Universit£
Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives.
Lomonosov Moscow State University
Synthesis, anti-HIV activity, integrase enzyme inhibition and molecular modeling of catechol, hydroquinone and quinol labdane analogs.
Mumbai University
6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.
"Sapienza" Universit£
Synthesis, docking, and biological studies of phenanthrene ?-diketo acids as novel HIV-1 integrase inhibitors.
University of Tennessee Health Science Center
Design and synthesis of novel pyrimidone analogues as HIV-1 integrase inhibitors.
Shandong University
Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.
University of Southern California
4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.
Universit£
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).
Glaxosmithkline Research & Development
Notable difference in anti-HIV activity of integrase inhibitors as a consequence of geometric and enantiomeric configurations.
University of Georgia
Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.
Shanghai Institute of Materia Medica
Inhibition of HIV-1 integrase dimerization and activity with crosslinked interfacial peptides.
Purdue University
Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
Universit£
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.
Purdue University
Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.
University of Southern California
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
University of Southern California
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.
Glaxosmithkline Research & Development
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.
Frederick National Laboratory For Cancer Research
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Chinese Academy of Sciences
Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.
East China University of Science and Technology
Carbamoyl pyridone HIV-1 integrase inhibitors. 1. Molecular design and establishment of an advanced two-metal binding pharmacophore.
Shionogi
Thiazoline peptides and a tris-phenethyl urea from Didemnum molle with anti-HIV activity.
University of Utah
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.
University of Lille
Structure-Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors.
Lomonosov Moscow State University
Design and synthesis of novel ?-diketo derivatives as HIV-1 integrase inhibitors.
Beijing University of Technology
Synthesis, structure-activity relationships, and mechanism of action of anti-HIV-1 lamellarin ? 20-sulfate analogues.
Nagasaki University
Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors.
Glaxosmithkline Research & Development
Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.
Chinese Academy of Sciences
Ethyl malonate amides: a diketo acid offspring fragment for HIV integrase inhibition.
University of Silesia
Exploring molecular shape analysis of styrylquinoline derivatives as HIV-1 integrase inhibitors.
Jadavpur University
Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
National Cancer Institute-Frederick
Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Pfizer
Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition.
Facult£S Universitaires Notre-Dame De La Paix (Fundp)
6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase.
University of Minnesota
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.
Shionogi
Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.
University of Tennessee Health Science Center
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Katholieke Universiteit Leuven
Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5.
National Institute of Pharmaceutical Education and Research
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.
University of Messina
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.
University of Lille
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.
Gilead Sciences
Inhibitors of strand transfer that prevent integration and inhibit human T-cell leukemia virus type 1 early replication.
Universit£
Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.
Merck And
Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold.
University of Southern California
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
Glaxosmithkline
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.
Avexa
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: selection of the scaffold.
Avexa
Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.
Tokyo Medical and Dental University
Tricyclononene carboxamide derivatives as novel anti-HIV-1 agents.
Beijing Institute of Biotechnology
Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.
Beijing University of Technology
Antiviral agents 2. Synthesis of trimeric naphthoquinone analogues of conocurvone and their antiviral evaluation against HIV.
Monash University (Parkville Campus)
Development of 2-pyrrolidinyl-N-methyl pyrimidones as potent and orally bioavailable HIV integrase inhibitors.
Irbm-Mrl
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.
Universit£
CoMFA and CoMSIA 3D-QSAR studies on quionolone caroxylic acid derivatives inhibitors of HIV-1 integrase.
Lanzhou University
New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.
Universit£
Peptide HIV-1 integrase inhibitors from HIV-1 gene products.
Tokyo Medical and Dental University
Synthesis and anti-HIV-1 integrase activity of modified dinucleotides.
Affiliated With The University of Orl£Ans and With Inserm Rue Charles Sadron
Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum.
University of Toyama
Multivariate QSAR study of 4,5-dihydroxypyrimidine carboxamides as HIV-1 integrase inhibitors.
Universidade Estadual Do Oeste Do Paran£
Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds.
The Hebrew University of Jerusalem
Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.
National Cancer Institute-Frederick
Analysis of binding parameters of HIV-1 integrase inhibitors: correlates of drug inhibition and resistance.
University of Cyprus
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.
Irbm-Merck Research Laboratories Rome
Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor.
Facult£S Universitaires Notre-Dame De La Paix
Design and synthesis of novel nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors from caffeic acid phenethyl ester.
Shandong University
N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors.
Irbm-Mrl
Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.
National Cancer Institute-Frederick
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.
National Cancer Institute
Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors.
Jt
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
National Cancer Institute
Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.
Universit£
Synthesis and anti-HIV-1 integrase activities of 3-aroyl-2,3-dihydro-1,1-dioxo-1,4,2-benzodithiazines.
Medical University of Gda?Sk
Amide-containing diketoacids as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity.
Shandong University
3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors.
Merck Research Laboratories Rome
Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors.
Universit£
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.
Zhejiang University
Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.
Universita Di Messina
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.
Universit£
Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase inhibitors.
University of Southern California
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Merck Research Laboratories
Brominated polyacetylenes from the Philippines sponge Diplastrella sp.
University of California At San Diego
Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp.
Merck Research Laboratories
Synthesis and structure-activity relationship study of lamellarin derivatives.
Nagasaki University
Synthesis, anti-HIV-1 integrase, and cytotoxic activities of 4-chloro-N-(4-oxopyrimidin-2-yl)-2-mercaptobenzenesulfonamide derivatives.
Medical University of Gdansk
Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones.
Universit£
Synthesis and antiviral properties of some polyphenols related to Salvia genus.
Umr Cnrs 8009
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.
Universita Degli Studi Di Siena
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors.
Chinese Academy of Sciences
Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.
Fondazione Cenci Bolognettiuniversit£
Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation.
Chinese Academy of Sciences
Dolastatin 3 and two novel cyclic peptides from a palauan collection of Lyngbya majuscula.
University of California At San Diego
A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase.
Korea Institute of Science & Technology
Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
Korea Institute of Science and Technology
Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides.
The Hebrew University of Jerusalem
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
Merck Research Laboratories
Isolation, structure, absolute stereochemistry, and HIV-1 integrase inhibitory activity of integrasone, a novel fungal polyketide.
Merck Research Laboratories
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.
Universit£
Development of 2-t butyl-N-methyl pyrimidones as potent inhibitors of HIV integrase.
Irbm-Mrl Rome
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.
Universit£
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.
Hebrew University of Jerusalem
Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors.
University of Southern California
2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.
National Cancer Institute-Frederick
Calculation of binding energy using BLYP/MM for the HIV-1 integrase complexed with the S-1360 and two analogues.
Universidade Federal Do Par£
Development of integrase inhibitors for treatment of AIDS: an overview.
K.L.E.S. College of Pharmacy
Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.
University of Southern California
Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore.
University of Southern California
Newer tetracycline derivatives: synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase.
Birla Institute of Technology and Science
Synthesis and HIV-1 integrase inhibitory activity of spiroundecane(ene) derivatives.
Siberian Branch of The Russian Academy of Sciences
8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Merck Research Laboratories
Substituted 2-pyrrolinone inhibitors of HIV-1 integrase.
University of Southern California
Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.
Merck Research Laboratories
Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA.
National Cancer Institute
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.
Universit£
Caffeoylglycolic and caffeoylamino acid derivatives, halfmers of L-chicoric acid, as new HIV-1 integrase inhibitors.
Korea Institute of Science & Technology
From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety.
Irbm-Mrl Rome
Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.
University of Tennessee Health Science Center
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H.
University of Minnesota
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.
University of Minnesota
Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors.
University of Southern Mississippi
DNA sequence-specific ligands. XVII. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric bisbenzimidazoles DBA(n).
Engelhardt Institute of Molecular Biology Russian Academy of Sciences
Synthesis and evaluation of substituted 4-arylimino-3-hydroxybutanoic acids as potential HIV-1 integrase inhibitors.
Rhodes University
Design, synthesis and biological evaluation of (E)-3,4-dihydroxystyryl 4-acylaminophenethyl sulfone, sulfoxide derivatives as dual inhibitors of HIV-1 CCR5 and integrase.
Peking University
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.
Shandong University
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
University of Minnesota
The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.
Bristol-Myers Squibb Research and Development