165 articles for thisTarget
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2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.
University of Lille
The design of 8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors.
Glaxosmithkline
Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.
Shandong University
Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.
Universit£
Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.
University of Minnesota
Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors.
Beijing University of Technology
Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.
Glaxosmithkline
Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
Bristol-Myers Squibb Research and Development
A review on recent developments of indole-containing antiviral agents.
Central China Normal University
Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase.
Shandong University
3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.
University of Minnesota
Advances in rationally designed dual inhibitors of HIV-1 reverse transcriptase and integrase.
Wuhan Institute of Technology
3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.
University of Minnesota
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
Bristol-Myers Squibb Research and Development
Synthetic routes and structure-activity relationships (SAR) of anti-HIV agents: A key review.
Wuhan University of Technology
Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.
University of Minnesota
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.
Shandong University
Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.
University of Cagliari
Biological evaluation of molecules of the azaBINOL class as antiviral agents: Inhibition of HIV-1 RNase H activity by 7-isopropoxy-8-(naphth-1-yl)quinoline.
Oregon State University
An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
The Ohio State University
Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors.
University of Delhi
Synthesis of dihydropyrimidine ?,?-diketobutanoic acid derivatives targeting HIV integrase.
Univ. Orl£Ans Et Cnrs
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.
"Sapienza" Universit£
Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.
Universit£
Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.
Universit£
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.
"Sapienza" Universit£
Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.
National Cancer Institute-Frederick
Inhibiting the HIV integration process: past, present, and the future.
"Sapienza" Universit£
Specific features of HIV-1 integrase inhibition by bisphosphonate derivatives.
Lomonosov Moscow State University
Synthesis, anti-HIV activity, integrase enzyme inhibition and molecular modeling of catechol, hydroquinone and quinol labdane analogs.
Mumbai University
6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.
"Sapienza" Universit£
Synthesis, docking, and biological studies of phenanthrene ?-diketo acids as novel HIV-1 integrase inhibitors.
University of Tennessee Health Science Center
Design and synthesis of novel pyrimidone analogues as HIV-1 integrase inhibitors.
Shandong University
Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.
University of Southern California
4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.
Universit£
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).
Glaxosmithkline Research & Development
Notable difference in anti-HIV activity of integrase inhibitors as a consequence of geometric and enantiomeric configurations.
University of Georgia
Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.
Shanghai Institute of Materia Medica
Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
Universit£
Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.
University of Southern California
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
University of Southern California
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.
Glaxosmithkline Research & Development
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.
Frederick National Laboratory For Cancer Research
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Chinese Academy of Sciences
Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.
East China University of Science and Technology
Carbamoyl pyridone HIV-1 integrase inhibitors. 1. Molecular design and establishment of an advanced two-metal binding pharmacophore.
Shionogi
Thiazoline peptides and a tris-phenethyl urea from Didemnum molle with anti-HIV activity.
University of Utah
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.
University of Lille
Structure-Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors.
Lomonosov Moscow State University
Design and synthesis of novel ?-diketo derivatives as HIV-1 integrase inhibitors.
Beijing University of Technology
Synthesis, structure-activity relationships, and mechanism of action of anti-HIV-1 lamellarin ? 20-sulfate analogues.
Nagasaki University
Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors.
Glaxosmithkline Research & Development
Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.
Chinese Academy of Sciences
Ethyl malonate amides: a diketo acid offspring fragment for HIV integrase inhibition.
University of Silesia
Exploring molecular shape analysis of styrylquinoline derivatives as HIV-1 integrase inhibitors.
Jadavpur University
Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
National Cancer Institute-Frederick
Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Pfizer
Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: new structural insight into the HIV-1 integrase inhibition.
Facult£S Universitaires Notre-Dame De La Paix (Fundp)
6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase.
University of Minnesota
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.
Shionogi
Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.
University of Tennessee Health Science Center
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Katholieke Universiteit Leuven
Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5.
National Institute of Pharmaceutical Education and Research
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.
University of Messina
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.
University of Lille
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.
Gilead Sciences
Inhibitors of strand transfer that prevent integration and inhibit human T-cell leukemia virus type 1 early replication.
Universit£
Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.
Merck And
Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold.
University of Southern California
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
Glaxosmithkline
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.
Avexa
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: selection of the scaffold.
Avexa
Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.
Tokyo Medical and Dental University
Tricyclononene carboxamide derivatives as novel anti-HIV-1 agents.
Beijing Institute of Biotechnology
Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.
Beijing University of Technology
Antiviral agents 2. Synthesis of trimeric naphthoquinone analogues of conocurvone and their antiviral evaluation against HIV.
Monash University (Parkville Campus)
Development of 2-pyrrolidinyl-N-methyl pyrimidones as potent and orally bioavailable HIV integrase inhibitors.
Irbm-Mrl
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.
Universit£
CoMFA and CoMSIA 3D-QSAR studies on quionolone caroxylic acid derivatives inhibitors of HIV-1 integrase.
Lanzhou University
New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.
Universit£
Peptide HIV-1 integrase inhibitors from HIV-1 gene products.
Tokyo Medical and Dental University
Synthesis and anti-HIV-1 integrase activity of modified dinucleotides.
Affiliated With The University of Orl£Ans and With Inserm Rue Charles Sadron
Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum.
University of Toyama
Multivariate QSAR study of 4,5-dihydroxypyrimidine carboxamides as HIV-1 integrase inhibitors.
Universidade Estadual Do Oeste Do Paran£
Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds.
The Hebrew University of Jerusalem
Diketoacid-genre HIV-1 integrase inhibitors containing enantiomeric arylamide functionality.
National Cancer Institute-Frederick
Analysis of binding parameters of HIV-1 integrase inhibitors: correlates of drug inhibition and resistance.
University of Cyprus
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.
Irbm-Merck Research Laboratories Rome
Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor.
Facult£S Universitaires Notre-Dame De La Paix
Design and synthesis of novel nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors from caffeic acid phenethyl ester.
Shandong University
N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors.
Irbm-Mrl
Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones.
National Cancer Institute-Frederick
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.
National Cancer Institute
Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors.
Jt
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
National Cancer Institute
Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.
Universit£
Synthesis and anti-HIV-1 integrase activities of 3-aroyl-2,3-dihydro-1,1-dioxo-1,4,2-benzodithiazines.
Medical University of Gda?Sk
Amide-containing diketoacids as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity.
Shandong University
3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors.
Merck Research Laboratories Rome
Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors.
Universit£
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.
Zhejiang University
Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.
Universita Di Messina
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.
Universit£
Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase inhibitors.
University of Southern California
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Merck Research Laboratories
Brominated polyacetylenes from the Philippines sponge Diplastrella sp.
University of California At San Diego
Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp.
Merck Research Laboratories
Synthesis and structure-activity relationship study of lamellarin derivatives.
Nagasaki University
Synthesis, anti-HIV-1 integrase, and cytotoxic activities of 4-chloro-N-(4-oxopyrimidin-2-yl)-2-mercaptobenzenesulfonamide derivatives.
Medical University of Gdansk
Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones.
Universit£
Synthesis and antiviral properties of some polyphenols related to Salvia genus.
Umr Cnrs 8009
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.
Universita Degli Studi Di Siena
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors.
Chinese Academy of Sciences
Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.
Fondazione Cenci Bolognettiuniversit£
Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation.
Chinese Academy of Sciences
Dolastatin 3 and two novel cyclic peptides from a palauan collection of Lyngbya majuscula.
University of California At San Diego
A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase.
Korea Institute of Science & Technology
Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
Korea Institute of Science and Technology
Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides.
The Hebrew University of Jerusalem
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
Merck Research Laboratories
Isolation, structure, absolute stereochemistry, and HIV-1 integrase inhibitory activity of integrasone, a novel fungal polyketide.
Merck Research Laboratories
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.
Universit£
Development of 2-t butyl-N-methyl pyrimidones as potent inhibitors of HIV integrase.
Irbm-Mrl Rome
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.
Universit£
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.
Hebrew University of Jerusalem
Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors.
University of Southern California
2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors.
National Cancer Institute-Frederick
Calculation of binding energy using BLYP/MM for the HIV-1 integrase complexed with the S-1360 and two analogues.
Universidade Federal Do Par£
Development of integrase inhibitors for treatment of AIDS: an overview.
K.L.E.S. College of Pharmacy
Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.
University of Southern California
Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore.
University of Southern California
Newer tetracycline derivatives: synthesis, anti-HIV, antimycobacterial activities and inhibition of HIV-1 integrase.
Birla Institute of Technology and Science
Synthesis and HIV-1 integrase inhibitory activity of spiroundecane(ene) derivatives.
Siberian Branch of The Russian Academy of Sciences
8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Merck Research Laboratories
Substituted 2-pyrrolinone inhibitors of HIV-1 integrase.
University of Southern California
Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.
Merck Research Laboratories
Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA.
National Cancer Institute
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.
Universit£
Caffeoylglycolic and caffeoylamino acid derivatives, halfmers of L-chicoric acid, as new HIV-1 integrase inhibitors.
Korea Institute of Science & Technology
From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety.
Irbm-Mrl Rome
Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.
University of Tennessee Health Science Center
6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H.
University of Minnesota
6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.
University of Minnesota
Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors.
University of Southern Mississippi
DNA sequence-specific ligands. XVII. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric bisbenzimidazoles DBA(n).
Engelhardt Institute of Molecular Biology Russian Academy of Sciences
Synthesis and evaluation of substituted 4-arylimino-3-hydroxybutanoic acids as potential HIV-1 integrase inhibitors.
Rhodes University
Design, synthesis and biological evaluation of (E)-3,4-dihydroxystyryl 4-acylaminophenethyl sulfone, sulfoxide derivatives as dual inhibitors of HIV-1 CCR5 and integrase.
Peking University
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.
Shandong University
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
University of Minnesota