PMID

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Article Title

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Discovery of 2,8-diazaspiro[4.5]decane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating hypertension.

Toray Industries

The many faces of the adamantyl group in drug design.

University of Sydney

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.

Merck Research Laboratories

Orally bioavailable potent soluble epoxide hydrolase inhibitors.

University of California Davis

1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia.

Ar£Te Therapeutics

1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.

Department of Entomology and University of California Davis Cancer Center

Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase.

Department of Entomology and University of California Davis Cancer Center

Peptidyl-urea based inhibitors of soluble epoxide hydrolases.

University of California

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.

University of Barcelona (Ub)

Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells.

Goethe University Frankfurt

Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility.

Department of Entomology and University of California Davis Cancer Center

Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors.

Universitat De Barcelona

Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor ? Agonists/Soluble Epoxide Hydrolase Inhibitors.

Goethe-University

From the Design to the

Unitat Associada Al Csic

Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis.

Shenyang Pharmaceutical University

Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility.

University of California Davis

QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds.

The Pennsylvania State University

2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors:

Universitat De Barcelona

-Benzyl-linoleamide, a Constituent of

University of California Davis

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.

Goethe-University Frankfurt

Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors.

Universitat De Barcelona

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase.

Scripps Research Institute

Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.

University of California Davis

Adamantyl thioureas as soluble epoxide hydrolase inhibitors.

University of California Davis