PMID

Data

Article Title

Organization

Synthesis and evaluation of geldanamycin-estradiol hybrids.

Sloan-Kettering Institute For Cancer Research

Volume of Distribution in Drug Design.

Pharmacokinetics

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Infinity Pharmaceuticals

Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.

Shenyang Pharmaceutical University

Synthesis of Hsp90 dimerization modulators.

Memorial Sloan-Kettering Cancer Center

High-throughput screening for Hsp90 ATPase inhibitors.

The University of Kansas

Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer.

Fujian Medical University (Fmu)

4-Amino derivatives of the Hsp90 inhibitor CCT018159.

Vernalis

Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans.

Second Military Medical University

Structural modification aimed for improving solubility of lead compounds in early phase drug discovery.

Indian Institute of Technology (B.H.U.)

Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

Memorial Sloan-Kettering Cancer Center

Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.

Conforma Therapeutics

Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures.

Ribotargets

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

Memorial Sloan-Kettering Cancer Center

Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo.

Taipei Medical University

Discovery of novel Hsp90 C-terminal domain inhibitors that disrupt co-chaperone binding.

University of Auckland

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.

China Pharmaceutical University

Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains.

University of New South Wales

Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting.

Mansoura University

Fragment Linking Strategies for Structure-Based Drug Design.

Universit£

Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity.

Seoul National University

Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities.

Fujian Medical University (Fmu)

From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition.

The University of Notre Dame

Enzymatic biosynthesis and biological evaluation of novel 17-AAG glucoside as potential anti-cancer agents.

Bengbu Medical College

p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators.

China Pharmaceutical University

Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.

Chinese Academy of Sciences

High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.

Jiangsu Normal University

Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.

China Pharmaceutical University

Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors.

Korea University

Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer.

China Pharmaceutical University

Clinical candidates modulating protein-protein interactions: The fragment-based experience.

Taros Chemicals

Why Some Targets Benefit from beyond Rule of Five Drugs.

Boston University

Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design.

Istituto Di Chimica Del Riconoscimento Molecolare

C-terminal modulators of heat shock protein of 90?kDa (HSP90): State of development and modes of action.

Heinrich Heine University D£Sseldorf

Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators.

China Pharmaceutical University

Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors.

Montclair State University

Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.

University of Arizona

Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening.

Universit£

3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.

The University of Kansas

Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90.

Exelixis

Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.

Myrexis

Gambogic acid, a natural product inhibitor of Hsp90.

Oklahoma State University

Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.

Pfizer

Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.

Astex Therapeutics

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.

Universit£

Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues.

The University of Kansas

Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.

Pfizer

Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors.

Poniard Pharmaceuticals

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

Serenex

Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.

Pfizer

Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.

The University of Kansas

Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay.

Emory University

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.

Emory University

Derrubone, an inhibitor of the Hsp90 protein folding machinery.

The University of Kansas

Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90).

National University of Singapore

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.

University of Vienna

Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.

China Pharmaceutical University

Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction.

China Pharmaceutical University