PMID

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Article Title

Organization

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.

The University of Kansas

Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.

Shandong University

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.

Sloan-Kettering Institute For Cancer Research

Development of radamide analogs as Grp94 inhibitors.

The University of Kansas

Identification of novel HSP90a/ß isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.

Vertex Pharmaceuticals

Correlation between chemotype-dependent binding conformations of HSP90a/ß and isoform selectivity-Implications for the structure-based design of HSP90a/ß selective inhibitors for treating neurodegenerative diseases.

Vertex Pharmaceuticals

EC144 is a potent inhibitor of the heat shock protein 90.

Biogen Idec

Heat shock protein 90: inhibitors in clinical trials.

Biogen Idec

Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects.

China Pharmaceutical University

Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors.

Taiho Pharmaceutical

Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.

Ewha Womans University

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90.

China Pharmaceutical University

Biological Evaluation of 5'-(

National Institute of Diabetes and Digestive and Kidney Diseases

Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.

Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.

China Pharmaceutical University

Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.

China Pharmaceutical University