PMID

Data

Article Title

Organization

Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1.

Leiden University

Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?

Merck Research Laboratories

Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.

Merck Research Laboratories

Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.

Universit£

Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation.

Parke-Davis Pharmaceutical Research

Ras farnesyltransferase: a new therapeutic target.

Warner-Lambert

Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.

University of Pittsburgh

Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase.

University College London

2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.

Merck Research Laboratories

Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I.

Wayne State University

Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.

Yale University

 

A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli

TBA

 

Cysteine and methionine linked by carbon pseudopeptides inhibit farnesyl transferase

TBA

Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc.

Pharmacopeia

Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I.

Janssen Research Foundation

Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.

Abbott Laboratories

Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

Merck Research Laboratories

Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.

Università

Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.

Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd)

Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.

Abbott Laboratories

Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor.

Abbott Laboratories

Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.

Imperial College

Antifungal activity of a Candida albicans GGTase I inhibitor-alanine conjugate. Inhibition of Rho1p prenylation in C. albicans.

Gpc Biotech

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.

Abbott Laboratories

5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.

Johnson & Johnson Pharmaceutical Research & Development

Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.

Abbott Laboratories

Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.

Abbott Laboratories

The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.

Merck Research Laboratories

Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

Merck Research Laboratories

A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor.

Banyu Tsukuba Research Institute

Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.

Yale University

A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase).

Lgci

Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.

Merck Research Laboratories

Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.

Merck Research Laboratories

Diaryl ether inhibitors of farnesyl-protein transferase.

Merck Research Laboratories

Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

Merck Research Laboratories

Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.

Merck Research Laboratories

Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.

Bristol-Myers Squibb Pharmaceutical Research Institute

N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.

Merck Research Laboratories

Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.

Merck Research Laboratories

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

Yale University

Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.

Schering-Plough Research Institute

Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods.

Schering-Plough Research Institute

Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins.

Università

Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.

Bristol-Myers Squibb Pharmaceutical Research Institute

Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.

Bristol-Myers Squibb Pharmaceutical Research Institute

Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.

University of Minnesota

Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.

Temple University

Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.

Janssen Research Foundation

A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity.

Duke University Medical Center

3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.

Merck Research Laboratories