PMID

Data

Article Title

Organization

Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase.

Pfizer

Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding.

Pfizer

Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones.

Pfizer

Substituted 6,7-dihydroimidazo[1,2-a]purin-9(4H)-ones.

TBA

Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics.

Lead Gene

7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.

Celltech R&D

Synthesis and profile of SCH351591, a novel PDE4 inhibitor.

Schering-Plough

8-Methoxyquinolines as PDE4 inhibitors.

Schering-Plough

8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.

Celltech R&D

Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors.

Korea Institute of Science and Technology

Synthesis and biological evaluation of 2,5-dihydropyrazol.

RhôNe-Poulenc Rorer

7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.

Celltech-Chiroscience

Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors.

Institut De Recherche Jouveinal-Parke Davis

Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.

Janssen-Cilag

A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.

Korea Institute of Science & Technology

Identification of purine inhibitors of phosphodiesterase 7 (PDE7).

Bristol-Myers Squibb Pharmaceutical Research Institute

Quinazolines: combined type 3 and 4 phosphodiesterase inhibitors.

Novartis Pharma

Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.

Pfizer

1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.

Smithkline Beecham Pharmaceuticals

Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors.

RhôNe-Poulenc Rorer

Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors.

Dipartimento Di Scienze Farmaceutiche, Firenze, Italy.