PMID

Data

Article Title

Organization

GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved

Genentech

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

Pharmaron-Beijing

Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists ors1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring.

Universit£

Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.

Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster

Some non-conventional biomolecular targets for diamidines. A short survey.

Xavier University of Louisiana

Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors.

University of Strasburg

5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.

Novartis Pharma

Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists.

University of Copenhagen

Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.

Friedrich-Schiller-Universitat Jena

Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity.

Takeda Pharmaceutical

SAGE-718: A First-in-Class

Sage Therapeutics

A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease.

Indian Institute of Technology (Banaras Hindu University)

Evaluation of ?-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors.

University of Jena

Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.

University Hospital Hradec Kralove

Repurposing of Drugs-The Ketamine Story.

University of Houston

Neuroactive Steroid

Sage Therapeutics

Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-? peptide in Alzheimer's disease.

Alma Mater Studiorum - University of Bologna

1

Janssen Research & Development

Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action.

University of Bristol

A New Class of Potent N-Methyl-D-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications.

Academy of Sciences of The Czech Republic V.V.I.

In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers.

Chiba University

Novel analogues of ketamine and phencyclidine as NMDA receptor antagonists.

Glaxosmithkline Medicines Research Centre

Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers.

Chiba University