PMID

Data

Article Title

Organization

Arylsulfonamide pyrimidines as VLA-4 antagonists.

Elan Pharmaceuticals

Fragment-based drug discovery.

Sunesis Pharmaceuticals

Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents.

Genentech

Structure-activity relationship (SAR) of thea-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.

Sunesis Pharmaceuticals

De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.

Cerep

Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives.

Boehringer Ingelheim Pharmaceuticals

New ?-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.

University of Bologna

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide.

Abbott Laboratories

Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.

Abbott Laboratories

Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations.

Pliant Therapeutics

Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion.

R. W. Johnson Pharmaceutical Research Institute