PMID

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Article Title

Organization

Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release.

University of Cambridge

Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists.

Abbott Laboratories

Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists.

Abbott Laboratories

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.

Glaxosmithkline

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.

Glaxosmithkline

Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.

Glaxosmithkline

Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.

Glaxosmithkline

Antagonists of the P2X(7) receptor. From lead identification to drug development.

Astrazeneca

Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain.

Abbott Laboratories

Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists.

Abbott Laboratories

Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists.

Abbott Laboratories

Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists.

Abbott Laboratories

Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor.

University of Bonn

Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists.

Abbott Bioresearch Center

Purine and pyrimidine (P2) receptors as drug targets.

National Institute of Diabetes

Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 2.

Merck Research Laboratories

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.

Amgen

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists.

Glaxosmithkline

Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 1.

Merck Research Laboratories

Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.

University of Sydney

Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists.

Abbott Bioresearch Center

Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.

Astrazeneca R&D Charnwood

Recent advancements in mechanistic studies and structure activity relationship of F

Kurukshetra University