BDBM50010462 CHEBI:78825::CHEMBL3264002::US11147816, RO5126766-(CH5126766)::US11701360, R05126766::US20230270730, Compound ref-5::US20230382863, Compound avutometinib

SMILES CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F

InChI Key InChIKey=LMMJFBMMJUMSJS-UHFFFAOYSA-N

Data  13 IC50  1 Kd

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50010462   

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Genuv

US Patent

LigandBDBM50010462(CHEBI:78825 | CHEMBL3264002 | US11147816, RO512676...)Copy SMILESCopy InChI

Affinity DataIC50:  160nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails US PatentPDB3D Structure (crystal)
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