BDBM32102 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione::1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone::MLS000087831::SMR000024051::US9284299, PKF118-310::US9738628, Compound PKF118-310::cid_66541

SMILES Cn1ncnc2c1nc(=O)n(C)c2=O

InChI Key InChIKey=SLGRAIAQIAUZAQ-UHFFFAOYSA-N

Data  14 KI  48 IC50  6 EC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 32102   

TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  184nMpH: 7.0 T: 2°CAssay Description:The MKP-1 HTS confirmation dose response assay has been developed to confirm actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibito...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50: >5.00E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-DTT assay has been developed to evaluate the effects of increased DTT concentration on the MKP-1 inhi...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50: >5.00E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-1...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  743nMAssay Description:The MKP-1 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-1 inhibit...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  98nMAssay Description:The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screenin...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  3.45E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT has been developed to assess actives that were identified in the Cdc25B HTS ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  551nMAssay Description:The Cdc25B Phosphatase probe assessment dose response reproducibility assay has been developed to re-confirm actives that were identified in the Cdc2...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50: >5.00E+4nMAssay Description:The MKP-3 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-3...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  535nMAssay Description:The MKP-3 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-3 inhibit...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  349nMAssay Description:The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  2.30E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Catalase has been developed to assess actives that were identified in the Cdc25B HTS A...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50: >5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT with Catalase has been developed to assess actives that were identified in t...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  3.24E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Beta-Mercaptoethanol (BME) has been developed to assess actives that were identified i...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  3.55E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Glutathione (GSH) has been developed to assess actives that were identified in the Cdc...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  433nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  423nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32102(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Affinity DataIC50:  396nMAssay Description:The MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment Cdc25B Dose Response Selectivity Assay has been developed to evaluate the PT...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay