BDBM6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955

SMILES CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1

InChI Key InChIKey=VAARYSWULJUGST-UHFFFAOYSA-N

Data  3 KI  13 IC50  451 Kd  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6568   

TargetTyrosine-protein kinase ABL1 [1-999,Q252H](Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM6568(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Affinity DataIC50:  24nMpH: 7.5Assay Description:An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1 [1-999,Q252H](Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM6568(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Affinity DataIC50:  23nMpH: 7.5Assay Description:An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester...More data for this Ligand-Target Pair