BDBM112499 DACOMITINIB::US8623883, No. 2::WO2022090481, Example dacomitinib
SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1
InChI Key InChIKey=LVXJQMNHJWSHET-AATRIKPKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 112499
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Massachusetts Medical School
Curated by ChEMBL
University Of Massachusetts Medical School
Curated by ChEMBL
Affinity DataEC50: 22nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A-431 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Massachusetts Medical School
Curated by ChEMBL
University Of Massachusetts Medical School
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Inhibition of EGFR T790M mutant phosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Massachusetts Medical School
Curated by ChEMBL
University Of Massachusetts Medical School
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR phosphorylation (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Massachusetts Medical School
Curated by ChEMBL
University Of Massachusetts Medical School
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of HER2 phosphorylation (unknown origin)More data for this Ligand-Target Pair