BDBM31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649
SMILES OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1
InChI Key InChIKey=HHFBDROWDBDFBR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 31093
Affinity DataKd: 68nMAssay Description:Binding affinity to BlkChecked by AuthorMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKd: 8nMAssay Description:Binding affinity to PRAK2Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of aurora A autophosphorylation in human HCT116 cells by immunofluorescence methodChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of aurora B in human HCT116 cells assessed as inhibition of histone H3 Ser10 phosphorylation by immunofluorescence methodChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 172nMAssay Description:Inhibition of aurora B kinaseChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of aurora A kinaseChecked by AuthorMore data for this Ligand-Target Pair