BindingDB BDBM4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US20240058459, Compound Sunit-inib::US9163010, Sunitinib::US9914707, SU11248

BDBM4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US20240058459, Compound Sunit-inib::US9163010, Sunitinib::US9914707, SU11248

SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C

InChI Key InChIKey=WINHZLLDWRZWRT-ATVHPVEESA-N

Data 38 KI 202 IC50 1451 Kd 1 EC50

PDB links: 12 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4814

Epidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 172nMAssay Description:Inhibition of EGFR in human A431 cells compound pretreated for 60 min before EGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 19nMAssay Description:Inhibition of VEGFR2 in human U251 cells compound pretreated for 60 min before VEGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot methodMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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PDB

3D Structure (crystal)

Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

IC50: 83nMAssay Description:Inhibition of PDGFR-beta in human U251 cells compound pretreated for 60 min before PDGF-BB stimulation for 10 mins by phosphotyrosine ELISA cytoblot ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Filter my 1692 hits

Targets 427▿
- Vascular endothelial growth factor receptor 2 69
- Receptor-type tyrosine-protein kinase FLT3 46
- Mast/stem cell growth factor receptor Kit 38
- Tyrosine-protein kinase ABL1 37
- Epidermal growth factor receptor 36
- Platelet-derived growth factor receptor beta 26
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 13
- Proto-oncogene tyrosine-protein kinase receptor Ret 11
- AP2-associated protein kinase 1 10
- Ribosomal protein S6 kinase alpha-5 10
- Ribosomal protein S6 kinase alpha-2 9
- Ribosomal protein S6 kinase alpha-1 9
- Ephrin type-A receptor 6 9
- Macrophage colony-stimulating factor 1 receptor 9
- Vascular endothelial growth factor receptor 3 9
- Hepatocyte growth factor receptor 8
- Tyrosine-protein kinase JAK1 8
- Fibroblast growth factor receptor 1 8
- Ribosomal protein S6 kinase alpha-4 8
- Fibroblast growth factor receptor 3 8
- Vascular endothelial growth factor receptor 1 8
- Cyclin-G-associated kinase 7
- Serine/threonine-protein kinase PLK4 7
- Death-associated protein kinase 3 7
- Dual specificity protein kinase CLK4 7
- Dual specificity protein kinase CLK2 7
- High affinity nerve growth factor receptor 7
- Ribosomal protein S6 kinase alpha-6 7
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 7
- Focal adhesion kinase 1 7
- Platelet-derived growth factor receptor alpha 7
- Serine/threonine-protein kinase PAK 4 7
- Ribosomal protein S6 kinase alpha-3 7
- Proto-oncogene tyrosine-protein kinase Src 7
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 7
- Serine/threonine-protein kinase 17A 6
- Death-associated protein kinase 2 6
- Tyrosine-protein kinase Lck 6
- Dual specificity protein kinase TTK 6
- Serine/threonine-protein kinase 17B 6
- Serine/threonine-protein kinase 4 6
- Dual specificity protein kinase CLK1 6
- Tyrosine-protein kinase receptor UFO 6
- BMP-2-inducible protein kinase 6
- Serine/threonine-protein kinase 16 6
- Cyclin-dependent kinase 16 6
- Myosin light chain kinase 2, skeletal/cardiac muscle 6
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 6
- STE20-like serine/threonine-protein kinase 6
- ALK tyrosine kinase receptor 6
- Mitogen-activated protein kinase kinase kinase kinase 5 6
- Non-receptor tyrosine-protein kinase TYK2 6
- Mitogen-activated protein kinase 14 6
- Tyrosine-protein kinase Fgr 6
- Insulin receptor 6
- Aurora kinase A 6
- Fibroblast growth factor receptor 2 6
- Aurora kinase C 6
- Serine/threonine-protein kinase Nek2 6
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 6
- Tyrosine-protein kinase Lyn 6
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 6
- Ephrin type-B receptor 1 6
- TRAF2 and NCK-interacting protein kinase 6
- Myosin light chain kinase, smooth muscle 6
- Serine/threonine-protein kinase 3 5
- Serine/threonine-protein kinase 38-like 5
- Tyrosine-protein kinase Fer 5
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 5
- Calcium/calmodulin-dependent protein kinase type II subunit delta 5
- Receptor-interacting serine/threonine-protein kinase 1 5
- Calcium/calmodulin-dependent protein kinase kinase 1 5
- Calcium/calmodulin-dependent protein kinase kinase 2 5
- Potassium voltage-gated channel subfamily H member 2 5
- Bone morphogenetic protein receptor type-2 5
- Calcium/calmodulin-dependent protein kinase type 1D 5
- Serine/threonine-protein kinase B-raf 5
- Aurora kinase B 5
- Tyrosine-protein kinase HCK 5
- Calcium/calmodulin-dependent protein kinase type 1 5
- NUAK family SNF1-like kinase 1 5
- Serine/threonine-protein kinase PLK1 5
- Calcium/calmodulin-dependent protein kinase type II subunit beta 5
- Tyrosine-protein kinase ABL2 5
- Tyrosine-protein kinase Fyn 5
- MAP/microtubule affinity-regulating kinase 3 5
- Cyclin-dependent kinase 2 5
- Serine/threonine-protein kinase PAK 5 5
- Serine/threonine-protein kinase MARK2 5
- Serine/threonine-protein kinase PAK 6 5
- Tyrosine-protein kinase JAK2 5
- Serine/threonine-protein kinase Chk1 5
- Activated CDC42 kinase 1 5
- Tyrosine-protein kinase Yes 5
- Epithelial discoidin domain-containing receptor 1 5
- Death-associated protein kinase 1 4
- Serine/threonine-protein kinase D2 4
- Serine/threonine-protein kinase D3 4
- Serine/threonine-protein kinase D1 4
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 4
- Serine/threonine-protein kinase pim-3 4
- Cyclin-dependent kinase 7 4
- Serine/threonine-protein kinase pim-2 4
- Serine/threonine-protein kinase DCLK1 4
- Tyrosine-protein kinase FRK 4
- Serine/threonine-protein kinase DCLK2 4
- Serine/threonine-protein kinase DCLK3 4
- Testis-specific serine/threonine-protein kinase 1 4
- Interferon-induced, double-stranded RNA-activated protein kinase 4
- Cyclin-dependent kinase 17 4
- Mitogen-activated protein kinase kinase kinase kinase 3 4
- Mitogen-activated protein kinase kinase kinase kinase 1 4
- Mitogen-activated protein kinase kinase kinase kinase 4 4
- NUAK family SNF1-like kinase 2 4
- Casein kinase II subunit alpha 4
- Serine/threonine-protein kinase Nek7 4
- Cyclin-dependent kinase 14 4
- Myosin light chain kinase family member 4 4
- Mitogen-activated protein kinase kinase kinase 9 4
- Interleukin-1 receptor-associated kinase 3 4
- Mitogen-activated protein kinase kinase kinase 4 4
- Protein kinase C theta type 4
- Serine/threonine-protein kinase PAK 3 4
- RAC-alpha serine/threonine-protein kinase 4
- Dual specificity mitogen-activated protein kinase kinase 2 4
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 4
- Serine/threonine-protein kinase tousled-like 2 4
- Serine/threonine-protein kinase tousled-like 1 4
- Tyrosine-protein kinase JAK3 4
- Dual specificity mitogen-activated protein kinase kinase 1 4
- MAP/microtubule affinity-regulating kinase 4 4
- Serine/threonine-protein kinase 10 4
- Leucine-rich repeat serine/threonine-protein kinase 2 4
- Casein kinase I isoform gamma-3 4
- Serine/threonine-protein kinase SIK2 4
- Tyrosine-protein kinase Fes/Fps 4
- Casein kinase I isoform gamma-2 4
- Serine/threonine-protein kinase SIK1 4
- Casein kinase I isoform epsilon 4
- Casein kinase I isoform gamma-1 4
- BDNF/NT-3 growth factors receptor 4
- 3-phosphoinositide-dependent protein kinase 1 4
- Myosin-IIIb 4
- Ephrin type-A receptor 5 4
- Tyrosine-protein kinase ITK/TSK 4
- NT-3 growth factor receptor 4
- SRSF protein kinase 2 4
- Protein-tyrosine kinase 2-beta 4
- Tyrosine-protein kinase Mer 4
- Tyrosine-protein kinase Blk 4
- Serine/threonine-protein kinase N2 4
- Non-receptor tyrosine-protein kinase TNK1 4
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 4
- Calcium/calmodulin-dependent protein kinase type IV 4
- Serine/threonine-protein kinase N1 4
- Serine/threonine-protein kinase RIO1 4
- Calcium/calmodulin-dependent protein kinase type 1G 4
- Serine/threonine-protein kinase LATS1 4
- Serine/threonine-protein kinase RIO3 4
- Wee1-like protein kinase 4
- Serine/threonine-protein kinase PLK3 4
- Casein kinase I isoform delta 4
- Tyrosine-protein kinase receptor TYRO3 4
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 4
- RAC-beta serine/threonine-protein kinase 4
- Cyclin-dependent kinase 18 [3-474] 4
- Serine/threonine-protein kinase BRSK1 4
- Ankyrin repeat and protein kinase domain-containing protein 1 4
- Citron Rho-interacting kinase 4
- Serine/threonine-protein kinase 26 4
- Serine/threonine-protein kinase 24 4
- Serine/threonine-protein kinase BRSK2 4
- Serine/threonine-protein kinase 25 4
- Maternal embryonic leucine zipper kinase 4
- Serine/threonine-protein kinase MARK1 4
- Serine/threonine-protein kinase 33 4
- Ephrin type-B receptor 4 4
- SRSF protein kinase 1 4
- Mitogen-activated protein kinase kinase kinase 11 4
- Casein kinase II subunit alpha' 4
- Serine/threonine-protein kinase STK11 4
- Muscle, skeletal receptor tyrosine-protein kinase 4
- Tyrosine-protein kinase Tec 3
- Cyclin-dependent kinase 11B 3
- Receptor tyrosine-protein kinase erbB-2 3
- Cyclin-dependent kinase 11A 3
- LIM domain kinase 1 3
- LIM domain kinase 2 3
- Serine/threonine-protein kinase Nek9 3
- Glycogen synthase kinase-3 alpha 3
- Glycogen synthase kinase-3 beta 3
- Serine/threonine-protein kinase Nek6 3
- Serine/threonine-protein kinase Nek5 3
- Serine/threonine-protein kinase Nek1 3
- Serine/threonine-protein kinase receptor R3 3
- Serine/threonine-protein kinase PAK 1 3
- MAP kinase-interacting serine/threonine-protein kinase 2 3
- Serine/threonine-protein kinase PAK 2 3
- MAP kinase-interacting serine/threonine-protein kinase 1 3
- Dual specificity mitogen-activated protein kinase kinase 3 3
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 3
- Dual specificity mitogen-activated protein kinase kinase 6 3
- Dual specificity mitogen-activated protein kinase kinase 4 3
- Tyrosine-protein kinase ZAP-70 3
- Ephrin type-A receptor 1 3
- Ephrin type-A receptor 3 3
- Ephrin type-A receptor 2 3
- Myosin-IIIa 3
- Tyrosine-protein kinase BTK 3
- Ephrin type-A receptor 4 3
- Myotonin-protein kinase 3
- Protein kinase C eta type 3
- Insulin-like growth factor 1 receptor 3
- Activin receptor type-1 3
- Bone morphogenetic protein receptor type-1A 3
- Receptor-interacting serine/threonine-protein kinase 2 3
- Serine/threonine-protein kinase NLK 3
- Tyrosine-protein kinase Srms 3
- RAF proto-oncogene serine/threonine-protein kinase 3
- Dual specificity testis-specific protein kinase 1 3
- Ephrin type-B receptor 3 3
- Ephrin type-B receptor 2 3
- Tyrosine-protein kinase TXK 3
- MAP kinase-activated protein kinase 2 3
- Ephrin type-A receptor 8 3
- MAP kinase-activated protein kinase 5 3
- TGF-beta receptor type-2 3
- Tyrosine-protein kinase receptor Tie-1 3
- Proto-oncogene tyrosine-protein kinase ROS 3
- Cyclin-dependent kinase 9 3
- Cyclin-dependent kinase 8 3
- Serine/threonine-protein kinase TAO1 3
- Serine/threonine-protein kinase pim-1 3
- Cyclin-dependent kinase 5 3
- Cyclin-dependent kinase 3 3
- Serine/threonine-protein kinase 36 3
- Angiopoietin-1 receptor 3
- Serine/threonine-protein kinase TNNI3K 3
- Protein kinase C epsilon type 3
- Cyclin-dependent kinase 19 3
- Serine/threonine-protein kinase MRCK alpha 3
- Protein-tyrosine kinase 6 3
- Casein kinase I isoform alpha-like 3
- Mitogen-activated protein kinase 15 3
- Activin receptor type-1B 3
- Leukocyte tyrosine kinase receptor 3
- Cytoplasmic tyrosine-protein kinase BMX 3
- RAC-gamma serine/threonine-protein kinase 3
- Mitogen-activated protein kinase kinase kinase 5 3
- Atypical kinase COQ8B, mitochondrial 3
- cGMP-dependent protein kinase 2 3
- cGMP-dependent protein kinase 1 3
- Activin receptor type-2B 3
- Activin receptor type-2A 3
- Serine/threonine-protein kinase ULK3 3
- Mitogen-activated protein kinase 1 3
- Discoidin domain-containing receptor 2 3
- Mitogen-activated protein kinase 3 3
- Mitogen-activated protein kinase 4 3
- Protein kinase C delta type 3
- Mitogen-activated protein kinase 9 3
- Dual specificity protein kinase CLK3 3
- Mitogen-activated protein kinase 6 3
- cAMP-dependent protein kinase catalytic subunit beta 3
- Mitogen-activated protein kinase 7 3
- Mitogen-activated protein kinase 8 3
- Tyrosine-protein kinase SYK 3
- Serine/threonine-protein kinase TBK1 3
- Serine/threonine-protein kinase 32B 3
- Fibroblast growth factor receptor 4 3
- Serine/threonine-protein kinase RIO2 3
- Serine/threonine-protein kinase 32C 3
- Mitogen-activated protein kinase kinase kinase 20 3
- Atypical kinase COQ8A, mitochondrial 3
- Serine/threonine-protein kinase PLK2 3
- Insulin receptor-related protein 3
- Mitogen-activated protein kinase 12 3
- Mitogen-activated protein kinase 11 3
- Mitogen-activated protein kinase 10 3
- Serine/threonine-protein kinase LATS2 3
- Tyrosine-protein kinase CSK 3
- eIF-2-alpha kinase GCN2 3
- Serine/threonine-protein kinase Chk2 3
- cAMP-dependent protein kinase catalytic subunit PRKX 3
- Serine/threonine-protein kinase MRCK beta 3
- Serine/threonine-protein kinase MRCK gamma 3
- Mitogen-activated protein kinase kinase kinase 10 3
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2
- Receptor tyrosine-protein kinase erbB-4 2
- Rhodopsin kinase GRK1 2
- Serine/threonine-protein kinase 38 2
- Cyclin-dependent kinase 4 2
- Serine/threonine-protein kinase TAO3 2
- Serine/threonine-protein kinase 35 2
- Uncharacterized serine/threonine-protein kinase SBK3 2
- Sodium channel protein type 5 subunit alpha 2
- Receptor tyrosine-protein kinase erbB-3 2
- Mitogen-activated protein kinase kinase kinase kinase 2 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Cyclin-dependent kinase 15 2
- Mitogen-activated protein kinase kinase kinase 6 2
- Macrophage-stimulating protein receptor 2
- Interleukin-1 receptor-associated kinase 1 2
- Mitogen-activated protein kinase kinase kinase 7 2
- Mitogen-activated protein kinase kinase kinase 2 2
- Cyclin-dependent kinase-like 3 2
- Mitogen-activated protein kinase kinase kinase 1 2
- Cyclin-dependent kinase-like 2 2
- Serine/threonine-protein kinase SIK3 [59-1321] 2
- Mitogen-activated protein kinase kinase kinase 3 2
- Homeodomain-interacting protein kinase 4 2
- Homeodomain-interacting protein kinase 3 2
- Serine/threonine-protein kinase ICK 2
- Cyclin-dependent kinase-like 5 2
- Microtubule-associated serine/threonine-protein kinase 1 2
- Protein delta homolog 1 2
- Megakaryocyte-associated tyrosine-protein kinase 2
- Rho-associated protein kinase 2 2
- Rho-associated protein kinase 1 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2
- Serine/threonine-protein kinase ULK1 2
- Serine/threonine-protein kinase ULK2 2
- Myosin light chain kinase 3 2
- Mitogen-activated protein kinase kinase kinase 19 2
- Ephrin type-A receptor 7 2
- Mitogen-activated protein kinase kinase kinase 15 2
- SRSF protein kinase 3 2
- G protein-coupled receptor kinase 4 2
- Bone morphogenetic protein receptor type-1B 2
- Homeodomain-interacting protein kinase 2 2
- Homeodomain-interacting protein kinase 1 2
- Receptor-interacting serine/threonine-protein kinase 4 2
- Ribosomal protein S6 kinase beta-1 2
- Hormonally up-regulated neu tumor-associated kinase 2
- Voltage-dependent L-type calcium channel subunit alpha-1C 2
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 2
- Serine/threonine-protein kinase OSR1 2
- Inhibitor of nuclear factor kappa-B kinase subunit beta 2
- Serine/threonine-protein kinase NIM1 2
- Serine/threonine-protein kinase MAK 2
- Serine/threonine-protein kinase/endoribonuclease IRE1 2
- Mitogen-activated protein kinase 13 2
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 2
- Wee1-like protein kinase 2 2
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma 2
- Casein kinase I isoform alpha 2
- Misshapen-like kinase 1 2
- cAMP-dependent protein kinase catalytic subunit alpha 2
- Protein kinase C alpha type 2
- Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] 2
- Ephrin type-B receptor 6 2
- Rhodopsin kinase GRK7 2
- Mitogen-activated protein kinase kinase kinase 12 2
- Mitogen-activated protein kinase kinase kinase 13 2
- STE20/SPS1-related proline-alanine-rich protein kinase 2
- Phosphatidylinositol 4-kinase beta 2
- Bile salt export pump 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 2
- Solute carrier family 22 member 1 1
- Tyrosine-protein kinase ABL1 [201-500,M351T] 1
- Calcium-dependent protein kinase 1 1
- Isoform 3 of Ribosomal protein S6 kinase alpha-2 (3) 1
- Tyrosine-protein kinase ABL1 [201-500,Q252H] 1
- Peripheral plasma membrane protein CASK 1
- Dual serine/threonine and tyrosine protein kinase 1
- Potassium voltage-gated channel subfamily D member 3 1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 1
- Beta-adrenergic receptor kinase 1 1
- Tubulin alpha-1A chain 1
- Serine/threonine-protein kinase PknB 1
- Serine/threonine-protein kinase PRP4 homolog 1
- Serine/threonine-protein kinase TAO2 1
- Cyclin-dependent kinase-like 1 [2-358] 1
- Cyclin-dependent kinase 2 homolog 1
- 5'-AMP-activated protein kinase subunit beta-2 1
- Broad substrate specificity ATP-binding cassette transporter ABCG2 1
- Cyclin-dependent kinase 13 1
- Protein kinase C iota type 1
- Interleukin-1 receptor-associated kinase 4 1
- Transient receptor potential cation channel subfamily M member 6 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek3 1
- Serine/threonine-protein kinase VRK2 1
- Tyrosine-protein kinase ABL1 [201-500,Y253F] 1
- Tyrosine-protein kinase ABL1 [T315I] 1
- P2Y purinoceptor 14 1
- Tyrosine-protein kinase ABL1 [201-500] 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- Potassium voltage-gated channel subfamily E/KQT member 1 1
- ATP-binding cassette sub-family C member 2 1
- Mast/stem cell growth factor receptor Kit [V559D,T670I] 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 1
- Dual specificity mitogen-activated protein kinase kinase 5 1
- NAD-dependent protein deacetylase sirtuin-2 1
- Tyrosine-protein kinase ABL1 [201-500,E255K] 1
- Serine/threonine-protein kinase Sgk3 1
- Bromodomain-containing protein 7 1
- Bromodomain-containing protein 9 1
- Serine/threonine-protein kinase Nek11 1
- Serine/threonine-protein kinase mTOR 1
- Eukaryotic translation initiation factor 2-alpha kinase 1 1
- Tyrosine-protein kinase ABL1 [201-500,T315N] 1
- G protein-coupled receptor kinase 5 1
- Poly [ADP-ribose] polymerase tankyrase-2 1
- Acetylcholinesterase 1
- Receptor-type tyrosine-protein kinase FLT3 [D835H] 1
- SNF-related serine/threonine-protein kinase 1
- Serine/threonine-protein kinase 32A 1
- Receptor-type tyrosine-protein kinase FLT3 [D835Y] 1
- Tyrosine-protein kinase ABL1 [201-500,H396P] 1
- Tyrosine-protein kinase ABL1 [201-500,F359V] 1
- Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S 1
- U4/U6 small nuclear ribonucleoprotein Prp4 1
- Tyrosine-protein kinase ABL1 [201-500,T315I] 1
- Mast/stem cell growth factor receptor Kit [V559D] 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1
- Receptor-type tyrosine-protein kinase FLT3 [N841I] 1
- Mast/stem cell growth factor receptor Kit [N822K] 1
- Dual specificity protein kinase CLK1 [R432A] 1
- Serine/threonine-protein kinase SBK1 1
- Epidermal growth factor receptor [G719C] 1
- Bifunctional epoxide hydrolase 2 1
- Ephrin type-A receptor 3 [1-975] 1
- Tyrosine-protein kinase ABL1 [1-999,Q252H] 1
- ...
Publications 50▿
- Nat Biotechnol 29: 1046-51 (2011) 442
- Blood 114: 2984-92 (2009) 360
- Nat Biotechnol 26: 127-32 (2008) 317
- Nat Biotechnol 23: 329-36 (2005) 79
- Proc Natl Acad Sci U S A 104: 19936-41 (2007) 46
- PubChem Bioassay (2008) 33
- Proc Natl Acad Sci U S A 102: 11011-6 (2005) 12
- Eur J Med Chem 46: 4311-23 (2011) 9
- J Pharmacol Toxicol Methods 70: 246-54 (2014) 9
- J Med Chem 64: 4870-4890 (2021) 9
- J Med Chem 64: 11747-11773 (2021) 6
- Eur J Med Chem 82: 139-51 (2014) 6
- J Med Chem 53: 1413-37 (2010) 5
- Bioorg Med Chem Lett 20: 6129-32 (2010) 5
- Eur J Med Chem 53: 254-63 (2012) 5
- Bioorg Med Chem 19: 5342-51 (2011) 5
- Bioorg Med Chem 25: 3500-3511 (2017) 4
- Bioorg Med Chem 18: 4674-86 (2011) 4
- J Med Chem 53: 8140-9 (2010) 4
- Toxicol Sci 136: 216-41 (2013) 4
- Biochemistry 46: 9551-63 (2007) 4
- Eur J Med Chem 127: 72-86 (2017) 4
- J Med Chem 46: 1116-9 (2003) 4
- Bioorg Med Chem 18: 1482-96 (2010) 4
- Bioorg Med Chem 56: (2022) 3
- Bioorg Med Chem 22: 3753-72 (2014) 3
- Bioorg Med Chem 21: 1857-64 (2013) 3
- Bioorg Med Chem 35: (2021) 3
- Bioorg Med Chem 21: 1312-23 (2013) 3
- Bioorg Med Chem 20: 910-4 (2012) 3
- J Med Chem 62: 2428-2446 (2019) 3
- Bioorg Med Chem Lett 22: 4979-85 (2012) 3
- J Med Chem 55: 725-34 (2012) 3
- Eur J Med Chem 197: (2020) 3
- Bioorg Med Chem 18: 5261-73 (2010) 3
- Bioorg Med Chem 20: 4217-25 (2012) 3
- Bioorg Med Chem Lett 28: 3085-3093 (2018) 3
- Eur J Med Chem 184: (2019) 3
- J Med Chem 62: 3940-3957 (2019) 3
- Bioorg Med Chem 23: 2408-23 (2015) 3
- Bioorg Med Chem 18: 3575-87 (2010) 3
- Eur J Med Chem 126: 754-761 (2017) 3
- Eur J Med Chem 179: 147-165 (2019) 2
- J Med Chem 58: 3672-81 (2015) 2
- J Med Chem 62: 11135-11150 (2019) 2
- Eur J Med Chem 199: (2020) 2
- J Med Chem 60: 248-262 (2017) 2
- J Med Chem 63: 3227-3237 (2020) 2
- J Med Chem 65: 893-921 (2022) 2
- J Med Chem 65: 935-954 (2022) 2
- ...
Institutions 35▿
- Ambit Biosciences 1231
- Harvard Medical School 46
- Duquesne University 30
- Ambit 12
- Universit£ 11
- Nanjing University Of Chinese Medicine 9
- University Of Oxford 9
- University Of Arkansas For Medical Sciences 6
- Qilu Pharmaceutical 6
- Schering-Plough 5
- Takeda Pharmaceutical 5
- Technische Universit£T Braunschweig 5
- National Health Research Institutes 5
- Industrial Technology Research Institute 5
- Shenyang Pharmaceutical University 4
- Abbott Laboratories 4
- Shanghai Hengrui Pharmaceuticals 4
- Amgen 4
- National Taiwan University 4
- Sugen 4
- University Of Milano-Bicocca 4
- East China University Of Science And Technology 4
- Ain Shams University 3
- Technische Universit£T Darmstadt 3
- Vichem Chemie Research 3
- University Of Kentucky 3
- University Of Colorado Anschutz Medical Campus 3
- Exelixis 3
- Comenius University In Bratislava 3
- Centro De Investigaciones Biol�Gicas Margarita Salas (Csic) 2
- Central South University 2
- Csir-Indian Institute Of Integrative Medicine 2
- Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif) 2
- Moffitt Cancer Center 2
- Yunnan University 2
- ...
Affinity: 0.075 to 8.4E+6 nM▿
- Ki 38
- IC50 202
- Kd 1451
- EC50 1
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1