BDBM50056904 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid::CHEMBL171637::NSC-685589::Physodic acid, 5::cid_65751::physodic acid

SMILES CCCCCC(=O)Cc1cc(O)cc2Oc3c(OC(=O)c12)cc(O)c(C(O)=O)c3CCCCC

InChI Key InChIKey=KVTYWHGIZSCFLG-UHFFFAOYSA-N

Data  10 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50056904   

TargetKinesin-like protein KIF20B(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056904(3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11H...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in Escherichia coli B...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF20B(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056904(3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11H...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF20B(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056904(3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11H...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (2 to 477 residues) expressed in Es...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCentromere-associated protein E(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056904(3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11H...)
Affinity DataIC50:  9.14E+4nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of human CENP-E by pyruvate kinase/lactate dehydrogenase-linked assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCentromere-associated protein E(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056904(3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11H...)
Affinity DataIC50:  2.96E+4nMAssay Description:Inhibition of basal ATPase activity of human CENP-E by pyruvate kinase/lactate dehydrogenase-linked assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF20B(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056904(3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11H...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (2 to 477 residues) expressed in Escherichia coli BL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed