BDBM149404 AVL-301::CHEMBL3545308::CNX-419::CO-1686::Rociletinib::Tube721::US10167264, Compound CO-1686::US10300058, CO-1686::US10434101, Compound I-4::US11096942, Compound I-4::US8975249, I-4::US9783524, CO-1686

SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O

InChI Key InChIKey=HUFOZJXAKZVRNJ-UHFFFAOYSA-N

Data  2 KI  60 IC50  1 Kd  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 149404   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM149404(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Affinity DataIC50:  262nMAssay Description:Inhibition of wild type EGFR phosphorylation in human HaCaT cells incubated for 3 hrs by ELISA methodMore data for this Ligand-Target Pair