BDBM50010462 CHEBI:78825::CHEMBL3264002::US11147816, RO5126766-(CH5126766)::US11701360, R05126766::US20230270730, Compound ref-5::US20230382863, Compound avutometinib

SMILES CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F

InChI Key InChIKey=LMMJFBMMJUMSJS-UHFFFAOYSA-N

Data  13 IC50  1 Kd

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50010462   

TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50010462(CHEBI:78825 | CHEMBL3264002 | US11147816, RO512676...)
Affinity DataIC50:  292nMAssay Description:The test compound, CRAF (Thermo Fisher Scientific Inc.), MEK1 (Thermo Fisher Scientific Inc.) and ERK2 (Carna Biosciences, Inc.) were mixed in ATP-co...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50010462(CHEBI:78825 | CHEMBL3264002 | US11147816, RO512676...)
Affinity DataIC50:  11nMAssay Description:The test compound, BRAF (Eurofins Genomics KK.) and MEK1 (Thermo Fisher Scientific Inc.) were mixed in ATP-containing buffer and reacted for 90 minut...More data for this Ligand-Target Pair