BDBM50448785 CHEMBL3128069
SMILES C[C@@H](Oc1cc(cnc1N)-c1sc(nc1C)[C@](C)(O)CO)c1cc(F)ccc1-n1nccn1
InChI Key InChIKey=DIXMBHMNEHPFCX-MCMMXHMISA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50448785
Affinity DataKi: <0.100nMAssay Description:Inhibition of wild type human recombinant ALK kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-CONH...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of ALK L1196M mutant in mouse NIH-3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ALK L1196M (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of ALK in mouse NIH-3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human wild type EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.760nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair