BDBM186055 US9163011, 9

SMILES C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F

InChI Key InChIKey=CGFNKFZCIRBOAD-OAHLLOKOSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 186055   

TargetBeta-secretase 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM186055(US9163011, 9)
Affinity DataIC50:  4nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 1 nM concentrations is incubated wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM186055(US9163011, 9)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human BACE2 extracellular domain expressed in baculovirus using Q-C(HS03)-lle-Asp-Leu-Ala-Val-Leu-Asp-HN-CH2-CH2-Mca as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed