BindingDB BDBM30130 CHEMBL1201082::CHEMBL41::Fluoxetin::Fluoxetine::Prozac::US9120771, Fluoxetine::cid

BDBM30130 CHEMBL1201082::CHEMBL41::Fluoxetin::Fluoxetine::Prozac::US9120771, Fluoxetine::cid_62857

SMILES CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1

InChI Key InChIKey=RTHCYVBBDHJXIQ-UHFFFAOYSA-N

Data 169 KI 89 IC50 4 Kd 4 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30130

Cytochrome P450 2C8(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL

BDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)

Ki: 2.94E+5nMAssay Description:Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using a recombinant systemMore data for this Ligand-Target Pair

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Filter my 263 hits

Targets 51▿
- Sodium-dependent serotonin transporter 91
- Sodium-dependent dopamine transporter 33
- Sodium-dependent noradrenaline transporter 22
- 5-hydroxytryptamine receptor 2C 11
- 5-hydroxytryptamine receptor 2A 10
- Transporter 8
- Norepinephrine transporter 6
- Potassium voltage-gated channel subfamily H member 2 6
- Alpha-1A adrenergic receptor 5
- Histamine H1 receptor 5
- Histamine H3 receptor 4
- 5-hydroxytryptamine receptor 1A 4
- Muscarinic acetylcholine receptor M2 4
- D(2) dopamine receptor 3
- 5-hydroxytryptamine receptor 2B 3
- Acetylcholinesterase 3
- Bile salt export pump 3
- Alpha-2A adrenergic receptor 3
- Sigma non-opioid intracellular receptor 1 2
- Potassium channel subfamily K member 2 2
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 2
- Cytochrome P450 2C19 2
- 5-hydroxytryptamine receptor 7 2
- Muscarinic acetylcholine receptor M1 2
- Beta-arrestin-2 1
- Sigma intracellular receptor 2 1
- Muscarinic acetylcholine receptor M5 1
- Muscarinic acetylcholine receptor M4 1
- Muscarinic acetylcholine receptor M3 1
- Beta-2 adrenergic receptor 1
- ATP-dependent translocase ABCB1 1
- 5-hydroxytryptamine 1D receptor 1
- 5-hydroxytryptamine receptor 1B 1
- 5-hydroxytryptamine receptor 3A 1
- Voltage-dependent L-type calcium channel subunit alpha-1C 1
- Cytochrome P450 2C8 1
- Cytochrome P450 3A4 1
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 1
- Potassium voltage-gated channel subfamily C member 1 1
- Albumin 1
- Cytochrome P450 2J2 1
- Serotonin 2 (5-HT2) receptor 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- Cytochrome P450 1B1 1
- Alpha-2C adrenergic receptor 1
- ATP-binding cassette sub-family C member 2 1
- Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor 1
- D(1A) dopamine receptor 1
- 5-hydroxytryptamine receptor 6 1
- Ubiquitin-conjugating enzyme E2 N 1
- ...
Publications 50▿
- Cell Mol Neurobiol 19: 467-89 (1999) 13
- J Pharmacol Exp Ther 283: 1305-22 (1997) 12
- Encephale 28: 350-5 (2002) 10
- Psychopharmacology (Berl) 114: 559-65 (1994) 7
- Neuropsychopharmacology 5: 43-7 (1991) 6
- Bioorg Med Chem 17: 337-43 (2008) 6
- Bioorg Med Chem Lett 30: (2020) 6
- Bioorg Med Chem Lett 8: 487-92 (1999) 6
- Biochem Pharmacol 45: 2352-4 (1993) 5
- Neuropharmacology 36: 621-9 (1997) 5
- J Med Chem 44: 787-805 (2001) 5
- J Pharmacol Exp Ther 247: 1032-8 (1988) 5
- Toxicol Sci 136: 216-41 (2013) 4
- ACS Med Chem Lett 5: 999-1004 (2014) 3
- Circulation 102: 2836-41 (2000) 3
- Eur J Pharmacol 340: 249-58 (1997) 3
- Bioorg Med Chem 18: 8356-64 (2010) 3
- J Med Chem 48: 6023-34 (2005) 3
- Bioorg Med Chem Lett 16: 4345-8 (2006) 3
- J Med Chem 52: 1530-9 (2009) 3
- Neuropsychopharmacology 27: 699-711 (2002) 3
- J Pharmacol Exp Ther 226: 686-700 (1983) 3
- J Med Chem 43: 1215-22 (2000) 3
- Bioorg Med Chem Lett 17: 2566-9 (2007) 3
- Bioorg Med Chem Lett 18: 4224-7 (2008) 3
- Psychopharmacology (Berl) 126: 234-40 (1996) 3
- US Patent US9120771 (2015) 3
- Bioorg Med Chem Lett 17: 1047-51 (2007) 3
- Synapse 39: 32-41 (2001) 3
- Bioorg Med Chem Lett 19: 58-61 (2008) 3
- Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) 3
- J Med Chem 48: 6523-43 (2005) 3
- Bioorg Med Chem Lett 10: 2741-3 (2000) 3
- J Med Chem 63: 15187-15217 (2020) 3
- Bioorg Med Chem Lett 16: 4349-53 (2006) 3
- J Med Chem 45: 1930-41 (2002) 3
- Bioorg Med Chem Lett 17: 702-6 (2007) 3
- Bioorg Med Chem Lett 17: 4799-803 (2007) 3
- J Med Chem 55: 8188-92 (2012) 3
- Bioorg Med Chem Lett 18: 4495-8 (2008) 3
- Bioorg Med Chem Lett 24: 3234-7 (2014) 3
- J Med Chem 33: 2793-7 (1990) 3
- J Med Chem 49: 4785-9 (2006) 2
- Eur J Med Chem 53: 124-32 (2012) 2
- J Med Chem 51: 6980-7004 (2008) 2
- J Pharmacol Exp Ther 293: 686-96 (2000) 2
- J Med Chem 54: 2924-32 (2011) 2
- Bioorg Med Chem Lett 19: 2464-7 (2009) 2
- J Med Chem 62: 8881-8914 (2019) 2
- Neuropharmacology 32: 737-43 (1993) 2
- ...
Institutions 33▿
- Emory University 22
- TBA 13
- Mayo Clinic 10
- Eli Lilly 9
- Pfizer 9
- Korea Institute Of Science And Technology 9
- Georgetown University Medical Center 9
- Human Biomolecular Research Institute 9
- Mcneil Pharmaceutical 8
- Korea University 6
- Johnson & Johnson Pharmaceutical Research & Development 6
- Hong Kong University Of Science And Technology 6
- Neurocrine Biosciences 6
- Nih 6
- Wyeth Research 6
- Johnson & Johnson Pharmaceutical Research And Development 6
- Mayo Foundation 5
- Roche Bioscience 5
- Institut De Recherches Servier 5
- Amgen 4
- University Of New Orleans 3
- Organon Laboratories 3
- The State University Of New York 3
- Vernalis Research 3
- Soochow University 3
- University of Turku 3
- Bristol-Myers Squibb Pharmaceutical Research Institute 3
- Korea Institute of Science and Technology 3
- Florida A&M University 2
- Wake Forest University 2
- China Pharmaceutical University 2
- Wayne State University 2
- Boots Pharmaceuticals 2
- ...
Affinity: 0.72 to 4.8E+5 nM▿
- Ki 169
- IC50 89
- Kd 4
- EC50 4
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1