BDBM379634 US9926281, Compound 152

SMILES C[C@H]1CN(CCN1c1cccc(Cl)c1)C(=O)CCC1(NC(=O)NC1=O)C1CC1

InChI Key InChIKey=IABWDXKLHPEEBX-SZQRVLIRSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 379634   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM379634(US9926281, Compound 152)
Affinity DataIC50: >2.00E+4nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM379634(US9926281, Compound 152)
Affinity DataIC50:  1.28E+3nMAssay Description:Inhibition of human recombinant TACE (AA34 to 660) assessed as cleavage of fluorescent substrate using 5FAM-LAQAVRSSSRK-5TAMRA as substrate by bioche...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed