BDBM50446481 CHEMBL3110004::US10011611, TMP269::US10722597, Compound TMP-269

SMILES FC(F)(F)c1nc(no1)-c1cccc(c1)C(=O)NCC1(CCOCC1)c1nc(cs1)-c1ccccc1

InChI Key InChIKey=HORXBWNTEDOVKN-UHFFFAOYSA-N

Data  16 KI  38 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50446481   

TargetHistone deacetylase 9(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataKi:  19nMAssay Description:Inhibition of human HDAC9 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50:  19.4nMAssay Description:Inhibition of recombinant human HDAC9 using fluorogenic substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50:  43.3nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 9(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50:  49nMAssay Description:Inhibition of HDAC9 (unknown origin) using fluorogenic HDAC class 2a as substrate measured after 1 to 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
University Of East Anglia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50:  23.2nMAssay Description:Inhibition of human recombinant HDAC9 using trifluoroacetyl lysine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed