BDBM50237601 CHEMBL411941::CycloRGDfV::[(2S,5R,8S,11S)-5-Benzyl-11-(3-guanidino-propyl)-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl]-acetic acid::[5-Benzyl-11-(3-guanidino-propyl)-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl]-acetic acid(Cyclo (RGDfV))::c(RGDfV)::c-[-Arg-Gly-Asp-fV-]::c[Arg-Gly-Asp-(R)-Phe-Val]::cyclo(Arg-Gly-Asp-D-Phe-Val)
SMILES [#6]-[#6](-[#6])-[#6@@H]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-c2ccccc2)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6]-1=O
InChI Key InChIKey=YYQUWEHEBOMRPH-NYUBLWNDSA-N
Data 29 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50237601
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Displacement of [125I]echistatin from AlphaVbeta5 integrin receptorMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Displacement of [125I]-echistatin from alpha-v-beta-5 integrin receptorMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Displacement of [125I]Echistatin from human placental integrin alpha-V-beta-5 receptorMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Affinity DataIC50: 7.5nMAssay Description:Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta5 receptor after 3 hrs by microplate reader analysisMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Antagonist activity at alphaVbeta5 in human MCF7 cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinog...More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Istituto Di Ricerche Chimiche E Biochimiche G. Ronzoni
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of fibrinogen binding to alphaVbeta5 isolated form human mCf7 cells incubated for 1 hr by scintillation-proximity assay based competitive ...More data for this Ligand-Target Pair