BDBM32020 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyrocatechol::4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol::4-[4-[3,4-bis(oxidanyl)phenyl]-2,3-dimethyl-butyl]benzene-1,2-diol::BDBM166684::CHEMBL52::LOX inhibitor, N/A::MLS000069451::NORDIHYDROGUAIARETIC ACID::Nordihydroguaiaretic acid (NDGA)::SMR000059049::US10857082, Compound 2.18::cid_4534

SMILES CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1

InChI Key InChIKey=HCZKYJDFEPMADG-UHFFFAOYSA-N

Data  1 KI  54 IC50  9 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 32020   

TargetLipoxygenase(Glycine max (Soybean))
Csir-Indian Institute of Chemical Biology

LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataKi:  232nMAssay Description:The crystal structure of soybean lipoxygenase-1 (PDB code: 3PZW), was used in our docking experiments. The 3D structure of 3PZW was reported by Chrus...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLipoxygenase(Glycine max (Soybean))
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  9.23E+3nMpH: 7.0 T: 2°CAssay Description:The assay was progressed in 96-well microliter plates containing substrate, soybean LOX enzyme, and respective test substance at room temperature in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLipoxygenase(Glycine max)
University Of Zagreb

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of soybean LOX using sodium linoleate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLipoxygenase(Glycine max)
University Of Zagreb

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of soybean LOX assessed as reduction in conversion of sodium linoleate to 13-hydroperoxylinoleic acid by UV spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLipoxygenase(Glycine max)
University Of Zagreb

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  9.23E+3nMAssay Description:Inhibition of soybean lipoxygenase after 5 mins by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLipoxygenase(Glycine max)
University Of Zagreb

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of soybean lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLipoxygenase(Glycine max)
University Of Zagreb

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  500nMAssay Description:Inhibition of soybean lipoxygenase using sodium linoleate as substrate by UV-based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed