BindingDB BDBM81767 15-28-Somatostatin-28::CAS_38916-34-6::CB6417646::Somatostatin-14

BDBM81767 15-28-Somatostatin-28::CAS_38916-34-6::CB6417646::Somatostatin-14

SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O

InChI Key InChIKey=NHXLMOGPVYXJNR-ATOGVRKGSA-N

Data 109 KI 26 IC50 5 Kd 4 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 81767

Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 0.300nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 0.530nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 0.590nMAssay Description:Inhibition of human sst4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 0.740nMAssay Description:Displacement of [125I]-somatostatin from human SSTR4 expressed in CHO-K1 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(RAT)
Tulane University

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 0.860nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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GoogleScholar

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Somatostatin receptor type 4(RAT)
Tulane University

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 0.860nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

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Somatostatin receptor type 4(Mus musculus)
Sandoz Pharma

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 1.20nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 1.20nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 1.23nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 1.23nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 1.26nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 1.30nMAssay Description:Binding affinity towards human Somatostatin receptor type 4 (sst4) using Tyr11-[125I]-SRIF as radioligand was determined in CHO cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 1.34nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 1.76nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 1.76nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 4.07nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Ki: 4.07nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

IC50: 1.70nMAssay Description:Displacement of 125I-[LTT]-SRIF-28 from human sst4 receptor in CCL39 cells after 2 hrs by autoradiographyMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

IC50: 1.80nMAssay Description:Inhibition of human SSTR4 by radioligand binding assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

Kd: 4.10nMAssay Description:Binding assay at human somatostatin receptor 4 (hsst4) expressed in CCL-39 cells using LTT-CST-14-(Tyr10) as radioligand.More data for this Ligand-Target Pair

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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

IC50: 1.60nMAssay Description:Displacement of [125I]-[LTT]-SS28 from human SST4 receptor expressed in Chinese hamster CCL-39 cells after 2 hrs by autoradiographic analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Somatostatin receptor type 4(Homo sapiens (Human))
Royal Victoria Hospital

Curated by PDSP K_i Database

PNG

BDBM81767(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)

IC50: 0.0800nMAssay Description:Tested for inhibition of radioligand binding to cloned somatostatin receptor hSSTR4More data for this Ligand-Target Pair

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Filter my 144 hits

Targets 13▿
- Somatostatin receptor type 2 35
- Somatostatin receptor type 5 33
- Somatostatin receptor type 3 23
- Somatostatin receptor type 4 22
- Somatostatin receptor type 1 21
- Somatostatin receptor type 1/2/3/4/5 3
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- ATP-binding cassette sub-family C member 2 1
- Delta-type opioid receptor 1
- Melatonin receptor type 1B 1
- Mu-type opioid receptor 1
- Bile salt export pump 1
- ...
Publications 27▿
- Naunyn Schmiedebergs Arch Pharmacol 360: 488-99 (1999) 17
- Naunyn Schmiedebergs Arch Pharmacol 357: 483-9 (1998) 10
- Eur J Pharmacol 348: 311-20 (1998) 10
- Rev Physiol Biochem Pharmacol 133: 55-108 (1998) 8
- Neuropharmacology 39: 1443-50 (2000) 7
- J Med Chem 54: 5981-7 (2011) 6
- Bioorg Med Chem Lett 24: 103-7 (2014) 5
- Bioorg Med Chem Lett 11: 991-5 (2001) 5
- J Med Chem 46: 2334-44 (2003) 5
- Bioorg Med Chem Lett 15: 3555-9 (2005) 5
- Transplant Proc 29: 2599-600 (1997) 5
- Peptides 15: 1421-4 (1994) 5
- Front Neuroendocrinol 20: 157-98 (1999) 5
- Eur J Med Chem 73: 30-7 (2014) 5
- J Med Chem 44: 2460-8 (2001) 5
- Naunyn Schmiedebergs Arch Pharmacol 350: 441-53 (1994) 5
- Proc Natl Acad Sci U S A 95: 10836-41 (1998) 5
- Endocrinology 135: 2814-7 (1994) 5
- J Med Chem 40: 2241-51 (1997) 4
- Toxicol Sci 136: 216-41 (2013) 4
- J Biol Chem 267: 20422-8 (1992) 3
- Mol Pharmacol 43: 838-44 (1993) 3
- Bioorg Med Chem Lett 11: 741-5 (2001) 2
- Mol Pharmacol 44: 385-92 (1993) 2
- Eur J Med Chem 163: 148-159 (2019) 2
- J Med Chem 29: 2370-5 (1986) 2
- Bioorg Med Chem 24: 1793-810 (2016) 1
Institutions 21▿
- Novartis Pharma 42
- Institut Henri Beaufour 12
- German Institute of Human Nutrition 8
- University of Cambridge 7
- Salk Institute 6
- Merck Research Laboratories 5
- Sandoz Pharma 5
- Tulane University 5
- University of Pennsylvania 5
- Royal Victoria Hospital 5
- Eth Zurich 5
- Institute For Research In Biomedicine (Irb Barcelona) 5
- Inrastes 5
- Novartis Pharma Research 5
- Mcgill University 5
- Amgen 4
- University Of California San Diego 4
- University of Chicago 3
- TBA 2
- National University Of Ireland Galway 2
- Jagiellonian University Medical College 1
Affinity: 0.0016 to 1.3E+5 nM▿
- Ki 109
- IC50 26
- Kd 5
- EC50 4
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1