BDBM50056676 CHEMBL3341789

SMILES COc1cc(cc(OC)c1OC)-c1cc(cnc1C)-c1ccc(cc1)N1CCNCC1

InChI Key InChIKey=BHUXVRVMMYAXKN-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50056676   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50056676(CHEMBL3341789)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50056676(CHEMBL3341789)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of ALK5 (unknown origin) transfected in human HEK293T cells cotransfected with CAGA reporter encoding luciferase by luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50056676(CHEMBL3341789)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50056676(CHEMBL3341789)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed