BDBM185700 US10875847, Compound Oclacitinib::US9161939, 1a::US9271981, 1a

SMILES CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12

InChI Key

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 185700   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Zoetis Services

US Patent
LigandPNGBDBM185700(US10875847, Compound Oclacitinib | US9161939, 1a |...)
Affinity DataIC50:  17.5nMpH: 7.4Assay Description:Methods: A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK-2 and JAK-3) or the IRS-1 peptide (JAK-1 and Tyk...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Zoetis Services

US Patent
LigandPNGBDBM185700(US10875847, Compound Oclacitinib | US9161939, 1a |...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant JAK2 (808 to 1132 residues) by Z-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed