BDBM16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one

SMILES O=C1c2ccccc2-c2n[nH]c3cccc1c23

InChI Key InChIKey=ACPOUJIDANTYHO-UHFFFAOYSA-N

Data  26 IC50  3 Kd

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16018   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM16018(14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexa...)
Affinity DataIC50:  957nMpH: 7.5 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit JAK3 RTK activity. The compounds were incubated with enzyme, 10 uM ATP, and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed