BDBM50172079 CHEMBL3809489

SMILES Nc1nc(Nc2ccc3CC[C@@H](CCc3c2)N2CCCC2)nn1-c1cc2CCCc3ccccc3-c2nn1

InChI Key InChIKey=KXMZDGSRSGHMMK-VWLOTQADSA-N

Data  33 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50172079   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  650nMAssay Description:Inhibition of AXL (unknown origin) measured by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50: <30nMAssay Description:Inhibition of recombinant AXL in human HeLa cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant AXL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of wild-type human partial length AXL (R497 to Y821 residues) expressed in bacterial expression system using poly [Glu, Try] 4:1 as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant AXL incubated for 1 to 1.5 hrs by FRET based Z'-Lyte kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  14nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant AXL incubated for 1 to 1.5 hrs by FRET based Z'-Lyte kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  14nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of AXL (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  14nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  14nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489)
Affinity DataIC50:  14nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed