BDBM14487 (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol::Adenine-beta-D-arabinofuranoside::Adenosine::CHEMBL477::N6-Methylado::[U-14C]adenosine::cid_191::cid_60961
SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
InChI Key InChIKey=OIRDTQYFTABQOQ-KQYNXXCUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 14487
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Broad Institute
Curated by PubChem BioAssay
Broad Institute
Curated by PubChem BioAssay
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Broad Institute
Curated by PubChem BioAssay
Broad Institute
Curated by PubChem BioAssay
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
Affinity DataEC50: 3.39E+3nMAssay Description:Effective concentration required for prolongation of the stimulus-QRS interval by 50% of the maximum response at the A1 adenosine receptor in langend...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 700nMAssay Description:Agonist activity at human recombinant adenosine receptor A2a by cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40E+4nMAssay Description:Agonist activity at human recombinant adenosine receptor A2b by cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 310nMAssay Description:Agonist activity at human recombinant adenosine A1 receptor by cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Agonist activity at human recombinant adenosine A3 receptor by cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 310nMAssay Description:Agonist activity at human adenosine A1 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinos...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 730nMAssay Description:Agonist activity at human adenosine A2A receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioino...More data for this Ligand-Target Pair
Affinity DataEC50: 2.35E+4nMAssay Description:Agonist activity at human adenosine A2B receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioino...More data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Agonist activity at human adenosine A3 receptor transfected in CHO cells assessed as changes in cAMP formation in the presence of nitrobenzylthioinos...More data for this Ligand-Target Pair
Affinity DataEC50: 2.51E+3nMAssay Description:Agonist activity at human Adenosine A1 receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphai1 after 16 hrs by beta galactosidase r...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 5.75E+3nMAssay Description:Agonist activity at human Adenosine A2A receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase r...More data for this Ligand-Target Pair
Affinity DataEC50: 5.13E+4nMAssay Description:Agonist activity at human Adenosine A2B receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase r...More data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 310nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 700nMAssay Description:Agonist activity at human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40E+4nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 4.00E+4nMAssay Description:Effective concentration required for cyclic AMP dependent inhibition of blood platelet aggregation for A2 receptor stimulationMore data for this Ligand-Target Pair
Affinity DataEC50: 3.39E+3nMAssay Description:Prolongation of the stimulus-QRS interval by 50% of the maximum response at the adenosine A1 receptor in langendorff guinea pig heart preparationChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.04E+3nMAssay Description:Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.41E+3nMAssay Description:Agonist activity at human A1AR assessed as induction of Ca2+ ion mobilization by orthogonal functional assayMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 290nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as increase of intracellular calcium levelMore data for this Ligand-Target Pair
Affinity DataEC50: 310nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as increase of intracellular calcium levelMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 700nMAssay Description:Agonist activity at human adenosine A2A receptor expressed in CHO cells assessed as increase of intracellular calcium levelMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40E+4nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as increase of intracellular calcium levelMore data for this Ligand-Target Pair
Affinity DataEC50: 51nMAssay Description:Concentration required for coronary arteries vasodilation at the A2 adenosine receptor in langendorff guinea pig heart preparationMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40E+4nMAssay Description:Agonist activity at A2B receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 69nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 25nMAssay Description:Agonist activity at human adenosine A2A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated fo...More data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated fo...More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair