BDBM4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194
SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
InChI Key InChIKey=YCOYDOIWSSHVCK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 79 hits for monomerid = 4851
Affinity DataIC50: 77nMpH: 7.5 T: 2°CAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
Affinity DataIC50: 54nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
Affinity DataIC50: 54nMT: 2°CAssay Description:In a representative synthetic procedure (compound 3), a mixture of 1 (330 mg, 2 mM) and 3-F3C-C6H4-NHNH2 (370 mg, 2.1 mM) in anisole (20 mL) was stir...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:In a representative synthetic procedure (compound 3), a mixture of 1 (330 mg, 2 mM) and 3-F3C-C6H4-NHNH2 (370 mg, 2.1 mM) in anisole (20 mL) was stir...More data for this Ligand-Target Pair
Affinity DataIC50: <15nMAssay Description:Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 138nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibition of Cyclin-dependent kinase 1 (CDK-1) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cyclin-dependent kinase 1More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Pharma
Curated by ChEMBL
Novartis Pharma
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-Src tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 730nMAssay Description:Inhibition of Proto-oncogene tyrosine-protein kinase KitMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Met proto-oncogene tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of vascular endothelial growth factor receptor 1More data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:In vitro inhibition of KDRMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against VEGFR-2 using 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against VEGFR-1 using 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 138nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of VEGFR1 by enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR2 by enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of VEGFR2 by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR1 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR2 (unknown origin) by HTRF assay in presence of 2 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of VEGFR1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of VEGF-induced phosphorylation of VEGFR2 (unknown origin) by cell-based ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of VEGFR2 (unknown origin) by HTRF assay in presence of 8 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR1 (unknown origin) by HTRF assay in presence of 8 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of VEGF-induced phosphorylation of VEGFR2 (unknown origin) by cell-based ELISA in presence of 8 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of VEGF-induced VEGFR2 phosphorylation (unknown origin) expressed in CHO cells in presence of 8 uM ATP by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 490nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibition of Insulin-like growth factor I receptor expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibition of Epidermal growth factor receptor (HER-1,ErbB) expressed in baculovirusMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibition of Met proto-oncogene tyrosine kinase (c-Met) expressed in baculovirusMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataIC50: 490nMAssay Description:In vitro inhibition of Platelet-derived growth factor receptor beta expressed in baculovirusMore data for this Ligand-Target Pair