BDBM106216 US9695174, 12A

SMILES COc1cc2[nH]c3[C@H](CC(C)C)N4[C@H](Cc3c2cc1C)C(=O)N[C@@H](C)C4=O

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 106216   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM106216(US9695174, 12A)
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:To determine potency of compounds on inhibition of transporters, bi-directional transport studies are performed in Caco-2 cells (American Type Cultur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM106216(US9695174, 12A)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM106216(US9695174, 12A)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed