BDBM127366 US8791131, 124

SMILES CCNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O

InChI Key InChIKey=IJYRWCXFZVEZEO-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127366   

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 127366BDBM127366(US8791131, 124)
Affinity DataKi:  4.04nM ΔG°:  -11.4kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent