BDBM127443 US8791131, 217

SMILES CNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnn(C)c2)n(C)c1=O

InChI Key InChIKey=AHYFVHIIOMCATP-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127443   

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 127443BDBM127443(US8791131, 217)
Affinity DataKi:  18.7nM ΔG°:  -10.5kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 127443BDBM127443(US8791131, 217)
Affinity DataKi:  26.2nM ΔG°:  -10.3kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent