BDBM175880 US9688684, Compound 77: 8-(2,3-Difluoro-phenyl)-7-thiophen-2-ylmethyl-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine

SMILES Fc1cccc(C2N(Cc3cccs3)CCn3nnnc23)c1F

InChI Key InChIKey=ROCBNWUPCDAHHB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 175880   

TargetNuclear receptor ROR-gamma [238-497](Human)
Merck Patent

US Patent
LigandPNGBDBM175880(US9688684, Compound 77: 8-(2,3-Difluoro-phenyl)-7-...)
Affinity DataIC50: 5.45E+3nMAssay Description:For the assay 12,500 293T cells (DSMZ no ACC 635) per 384 well are seeded in 30 μl inMEM Eagle medium, supplemented with 10% FBS, 2 mM Glutamax,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2018
Entry Details
US Patent

TargetNuclear receptor ROR-gamma [238-497](Human)
Merck Patent

US Patent
LigandPNGBDBM175880(US9688684, Compound 77: 8-(2,3-Difluoro-phenyl)-7-...)
Affinity DataIC50: 5.45E+3nMpH: 6.8Assay Description:In this assay, a GST-tagged human RORγ ligand binding domain (GST-hRORγ-LBD) interacts with a synthetic biotinylated TRAP220 cofactor pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2018
Entry Details
US Patent