BDBM195607 PHGDH-inactive::US11225469, Compound 71

SMILES Cc1cc(C)nc(NC(=S)N2CCN(CC2)c2ccncc2)c1

InChI Key InChIKey=ITLPIAAGIQAGRA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 195607   

TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195607(PHGDH-inactive | US11225469, Compound 71)
Affinity DataIC50: >5.70E+4nMpH: 8.0 T: 2°CAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195607(PHGDH-inactive | US11225469, Compound 71)
Affinity DataIC50: >2.00E+4nMAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195607(PHGDH-inactive | US11225469, Compound 71)
Affinity DataIC50: >5.70E+4nMAssay Description:Inhibition of human liver N-terminal His6-tagged PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3 -phosphoglycerate as substarte measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed